Oral-antidiabetic Drugs

Question 1

Explain what Sulfonylureas do

Answer 1

They stimulate the release of insulin from the islet pancreatic beta cells

Question 2

What dont we give sulfonylureas to patients with type 1?

Answer 2

Because the medication requires functioning beta cells

Question 3

What’s the common adverse reaction of sulfonylureas?

Answer 3

Hypoglycemia

Question 4

What is the Sulfonylurea of choice?

Answer 4

Glibenclamide

Question 5

Glibenclamide dosage

Answer 5

2.5mg/day, upped to 5-10mg maintance dose daily

Question 6

Why don’t we use Glibenclamide in patients of liver failure or CKD?

Answer 6

The risk of Hypoglycemia

Question 7

Glipizide is given to the elderly in place of Glibenclamide, why?

Answer 7

Lower potency and shorter duration of action. Essentially weaker

Question 8

We sometimes give Metformin and Thiazolidinedione, why?

Answer 8

As they don’t cause Hypoglycemia

Question 9

What is the GLP-1 receptor agonist of choice?

Answer 9

Liraglutide