(option) Neurobiology and Behavior Flashcards
What is a neuron?
- Neurons transmit electrical impulses throughout the nervous system
- 85 billion in the human NS
What are the three roles of neurons?
sensory, relay & motor
What are the three basic components of a neuron?
Dendrites – Short-branched fibers that convert chemical information from other neurons or receptor cells into electrical signals
Axon – An elongated fibre that transmits electrical signals to terminal regions for communication with other neurons or effectors
Soma – A cell body containing the nucleus and organelles, where essential metabolic processes occur to maintain cell survival
What is the purpose of the myelin sheath in neurons?
The myelin insulates the neuron and allows electrical impulses to pass very quickly.
Neurons generate and conduct electrical signals by pumping what across their membrane?
Na+ and K+
What is a membrane potential?
The unequal distribution of ions on different sides of the membrane creates a charge difference called the membrane potential
-70
ready to fire
In a typical resting position, what is the charge of a neuron?
Inside is more negative (approximately –70 mV)
How is the resting potential of a neuron maintained?
Sodium-pottasium pumps ( transmembrane protein) which require ATP
How does a sodium-potassium pump work?
- It expels 3 Na+ ions for every 2 K+ ions admitted (additionally, some K+ ions will then leak back out of the cell)
- This creates an electrochemical gradient whereby the cell interior is relatively negative compared to the extracellular environment (as there are more positively charged ions outside of the cell and more negatively charged ions inside the cell)
-The exchange of sodium and potassium ions requires the hydrolysis of ATP (it is an energy-dependent process)
What is an action potential?
Action potentials are the rapid changes in charge across the membrane that occur when a neuron is firing
What are the four main stages of an action potential?
resting potential, depolarization, repolarization and a refractory period
Depolarization
-what is it?
-what happens?
-70 → 30
Sodium in
via Sodium channel
In response to a signal initiated at a dendrite
Depolarization refers to a sudden change in membrane potential
As Na+ ions are more concentrated outside of the neuron, the opening of sodium channels causes a passive influx of sodium
The influx of sodium causes the membrane potential to become more positive (depolarisation)
Repolarization
-what is it?
-what happens?
30 → - 80
Potassium out
via Pottasium channel
Restoration of a membrane potential following depolarisation.
Following an influx of sodium, potassium channels open within the membrane of the axon
As K+ ions are more concentrated inside the neuron, opening potassium channels causes a passive efflux of potassium
The efflux of potassium causes the membrane potential to return to a more negative internal differential (repolarisation)
Refractory period
-what is it?
-what happens?
The refractory period refers to the period of time following a nerve impulse before the neuron is able to fire again
In a normal resting state, sodium ions are predominantly outside the neuron and potassium ions mainly inside (resting potential)
Following depolarization (sodium influx) and repolarisation (potassium efflux), this ionic distribution is largely reversed
Before a neuron can fire again, the resting potential must be restored via the sodium-potassium pump which requires ATP
What are nerve impulses?
Nerve impulses are action potentials that move along the length of an axon as a wave of depolarisation and repolitization
The ion channels that occupy the length of the axon are voltage-gated. What does this mean?
The depolarization in one segment of an axon triggers the next section to open ion channels to depolarize and therefore the impulse travels across the body of the axon.
What is myelin produced by?
Schwann cells
Pros and Cons of myelination of axons
The advantage of myelination is that it improves the speed of electrical transmission via saltatory conduction
The disadvantage of myelination is that it takes up significant space within an enclosed environment
Neurons transmit information across synapses by…?
converting the electrical signal into a chemical signal
Explain the chemical transfer across synapses
1) Action potential arrives at axon terminal
2) Voltage-gated CA2+ channels open
3) CA2+ enters presynaptic neuron
4) CA2+ signals to neurotransmitter vesicles
5) Neurotransmitters move to the membrane and dock
6) Neurotransmitters released by exocytosis
7) Neurotransmitters bind to receptors
8) Signal initiated in post-synaptic cell
What are neurotransmitters?
chemical messengers released from neurons that transmit signals across the synapse
What do neurotransmitters do?
- Neurotransmitters are released in response to the depolarisation of the axon terminal of a presynaptic neuron
- Neurotransmitters bind to receptors on post-synaptic cells and can either trigger (excitatory) or prevent (inhibitory) a response
What is an example of a neurotransmitter?
acetylcholine
It is commonly released at neuromuscular junctions and binds to receptors on muscle fibres to trigger muscle contraction
It is also commonly released within the autonomic nervous system to promote parasympathetic responses (‘rest and digest’)
What does acetylcholine do
-Plays a role in brain functions, such as memory, and body functions, such as muscle contractions to move your muscles Produced in pre-synaptic neuron by combining choline with acetyl group obtained from cellular respiration
- Acetylcholine binds to receptors in post-synaptic membrane and only remains bound there for a short time
- Acetylcholinesterase is present in the synaptic cleft and rapidly breaks down ac
- Choline reabsorbed and recombined with acetyl
- Action of neonicotinoids in insects: bind to acetylcholine receptors and thus block acetylcholine and paralyze insects
What do neonicitanoids do
Bind to acetylcholine receptors and thus block acetylcholine and paralyze insects
Insects have a different composition of acetylcholine receptors which bind to neonicotinoids much more strongly
Hence, neonicotinoids are significantly more toxic to insects than mammals, making them a highly effective pesticide
Bad for bees
Channels opened by excitatory vs inhibitory neurotransmitters and the polarization created
Excitatory neurotransmitters = depolarisation by opening sodium or calcium channels
Inhibitory neurotransmitters = hyperpolarisation by opening potassium or chlorine channels
For a typical neuron, the threshold potential (required to open voltage-gated ion channels) is approximately…..
–55 mV
The neural tube of embryonic chordates is formed by….
infolding of ectoderm followed by elongation of the tube
Neurons are initially produced by _______ in the _______________.
differentiation
neural tube
Immature neurons do what?
migrate to a final location
An axon grows from each immature neuron in response to…..
chemical stimuli
Some axons extend beyond the neural tube to reach….
other parts of the body
A developing neuron forms multiple…..
synapses
What happens to synapses that are not being used?
Synapses that are not used do not persist. This is called neural pruning
Neural pruning involves the loss of….
unused neurons