Optic Nerve/Neuro Flashcards

1
Q

Hyaloid Remnants/Persistent Hyaloid Artery

A
  • incomplete regression (usually done by 8 months)
  • asymptomatic
  • rare for vitreous hemorrhage
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2
Q

Prepapillary Vascular Loops

A
  • unilateral, arterial and embryonic in nature

Management:
- routine

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3
Q

Congenital Macrovessels

A
  • enlarged single vessel crossing the horizontal raphe

Management:
- recognition of leakages

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4
Q

Cilioretinal Vessels

A
  • usually derived from short posterior ciliary artery system or choroidal vascular system
  • positioned temporally, hooking out of papillomacular bundle
  • may remain patent even during CRAO because it is a different system

Management:

  • routine eye examination
  • occlusion may indicate giant cell arteritis
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5
Q

Myelinated Nerve Fibres

A
  • represent the continuation of normal myelinated tissue anterior to the lamina cribosa
  • superficial retinal opacification with feathered edges
  • may create visual field loss at threshold

Management:
- rule out CWS`

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6
Q

Choroidal Crescent

A
  • darker crescent due to absence of retina
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7
Q

Scleral Crescent

A
  • lighter/white crescent due to absence of choroid and retina
  • may be associated with ROP, ectasia and sickle cell proliferation
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8
Q

Circumpapillary Staphyloma

A
  • usually unilateral
  • area around the disc is depigmented and may have pigmentary migration
  • variably reduced vision or constricted fields
  • differential diagnosis helped with utlra sound

Management:

  • patient education and provision of safety eyewear
  • routine eye examinations indicated
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9
Q

Coloboma

  • absence of tissue due to failure of fetal tissue to close
A
  • affected nerve head always larger than its fellow, unusual looking
  • usually inferior portion affected with significant excavation and surround of pigment hyperplasia
  • reduced VA and VF defects variable but present
  • associated with systemic abnormalities
  • associated with non-rhegmatogenous retinal detachment and rhegmatogenous in retinochoridal variety

Management:

  • rule out systemic abnormalities
  • protective eyewear
  • ed RD
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10
Q

Morning Glory Disc

A
  • unilateral, affected head larger than its fellow
  • unusual vascular pattern radiating from disc
  • unilateral? severe vision loss. bilateral? mild-moderate.
  • strong association with non-rhegmatogenous detachment

Management:

  • rule out systemic involvement with neurological consultation
  • ed on RD
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11
Q

Congenital pits of the ONH

A
  • affected disc larger than its fellow
  • pit usually inferior temporal with VF loss
  • often associated with RPE disruption adjacent to ONH/reactive hyperplasia secondary to tugging of retinal tissue
  • strong association with non-rhegmatogenous retinal detachment
  • possible inheritance pattern

Management:

  • Amsler grid to monitor vision
  • Ed RD
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12
Q

Congenital optic nerve head hypoplasia

A
  • ONH 1/2 to 1/3 smaller than fellow eye
  • stronger association with astigmatism
  • reduced vision due to maldevelopment of NFL
  • variable VF defects (nasal or altitudinal)
  • associated with multiple systemic abnormalities especially if bilateral
  • present in 50% of fetal alcohol syndrome

Management:

  • rule out so it’s not treated as amblyopia
  • rule out systemic abnormalities
  • communication with other health care providers
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13
Q

Megalopapilla

A
  • unilateral enlarged disc of congenital nature secondary to abnormal development of primitive epithelial papilla
  • may stimulate asymmetric C/D of glaucomatous optic atrophy

Management:
- benign condition so just annual eye examinations

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14
Q

Buried Drusen

A
  • inherited in an autosomal irregular pattern
  • calcium-like deposits anterior to lamina cribosa
  • deposits can shear blood vessels, cause hemes,
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15
Q

Optic Neuritis

A
  • young female (20-45)
  • MS associated
  • unilateral, sudden, painful vision loss (VA 20/20 to NLP)
  • (+) RAPD
  • decreased vision sensitivity, VF defects
  • VA may return to normal/near normal over 2-3 months although will have permanent reduced CSF and optic nerve pallor.
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16
Q

Risk of developing MS after episode of optic neuritis?

A

15 year risk: 50%

72% if one or more white matter lesions are present on MRI, 25% if none.

17
Q

What are causes of optic neuritis?

A
  • idiopathic
  • Syphilis
  • Cat-scratch disease
  • Lyme disease
  • Meningitis
  • Sarcoidosis
  • Systemic lupus erythematosus
  • Devic’s disease (has no white lesions)
    • optic neuritis AND myelitis (spinal cord)
18
Q

Uhthoff’s phenomenon

A

Transient vision loss with increased body temperature (i.e. exercise). Highly characteristic of multiple sclereosis. Only occurs in 6% of patients though.

19
Q

Arteritic AION (AAION)

A
  • secondary occlusion of the short posterior ciliary arteries, most commonly due to giant cell arteritis (GCA)
  • -> systemic inflammation of the medium/large blood vessels
  • commonly occurs at age >55 years
  • elevated ESR, CRP and platelet count
  • Elevated ESR and CRP are 97% specific to GCA
20
Q

Leber’s optic neuropathy

A
  • hereditary condition that occurs from mutations in mitochondrial DNA that are inherited from the mother.
  • usually male and onsent in late teens/early 20s
  • commonly starts with one eye and sudden onset of decreased VA (20/200 to CF), before affecting other eye

Early signs; optic disc edema, disc hyperemia, telangiectatic vessels on surface of optic nerve

Late signs: optic disc atrophy

Conditions may spontaneously improve in 35% of cases.
No treatment.

21
Q

Optic nerve sheath meningioma

A
  • most common in young to middle-aged women
  • generally benign, unilateral tumours that result in compression of optic nerve with resulting optic disc edema, followed up optic atrophy and progressive vision loss

Treatment:
- observation, radiation, and/or surgery

22
Q

Ocular myasthenia

A
  • autoimmune antibodies against acetylcholine receptors in the neuromuscular junction
  • results in weakness and fatigue
  • Graves’ and Myasthenia can co-exist
  • decreased innervation to levator and EOM results in ptosis and diplopia
  • signs are variable and worse at end of the day due to patient fatigue
23
Q

Von Graefe’s sign

A

Upper lid lag during downgaze

24
Q

Kocher’s sign

A

Globe lag compared to eyelid movement during upgaze/lid retraction on gaze

25
Q

Dalrymple’s sign

A

Upper eyelid retraction with upper sclera showing resulting in stare appearance

26
Q

Lagophthlmos

A

Incomplete lid closure.

27
Q

Bell’s phenomenon

A

Eye deviate up and outwards with forced lid closure

28
Q

Pituitary adenoma is associated with?

A
  • bitemporal hemianopia
  • amenorrhea
  • galactorrhea
  • infertility
  • loss of libido
29
Q

Causes of chiasmal lesion

A
  • suprasellar meningioma
  • internal carotid artery aneurysm
  • craniopharyngiomas
  • gliomas
30
Q

Macula-only homonymous visual field defects should..?

A

Be imaged for compressive lesions.

Unlikely due to stroke reasons because of dual supply from middle cerebral and posterior cerebral arteries.

31
Q

Junctional scotoma

A

Temporal defect respecting the midline in “good” VA eye, and central/diffuse visual field defect in the fellow eye.

32
Q

Foster Kennedy Syndrome

A

Optic atrophy in one eye and optic edema in the other.. Tumour within the frontal lobe.

VF often normal in the edematous nerve, but central VF loss in atrophy.

33
Q

Macula-sparing homonymous hemianopia

spares at least central 5 degrees in both eyes

A

Most commonly due to stroke because macula fibers receive dual blood supply.

34
Q

Raised optic nerve differentials

A
  1. Papilledema
  2. Compressive optic neuropathy
  3. Optic neuritis: papillitis
  4. Central Retinal Vein Occlusion
  5. Ischemic Optic Neuropathy
35
Q

Papilledema causes

A
  1. papilledema
  2. idiopathic intracranial hypertension
  3. increased intracranial hypertension from space ocupying lesion in brain
36
Q

Idiopathic intracranial hypertension

A
  • abnormal CSF opening pressure (>250mmH20)
  • refer to neuro-ophth

GOALS:

  1. preserve vision
  2. decrease headaches
37
Q

Causes for space occupying lesions:

A
  • intracranial mass
  • sinus thrombosis
  • spinal cord mass
38
Q

Compressive optic neuropahy

A

Occurs when a lesion compresses along the optic nerve usually from within the orbit.

From globe to chiasm.
-chalked pale nerve