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(2) Introductory ocular disease > Optic Nerve Head > Flashcards

Optic Nerve Head Flashcards

1
Q

How are discs recorded?

A

• Drawing
• Which method used : Volk? 78D?

• C:D
• Rim/Disc

• Colour neuroretinal rim
• Margins - distinct, pigment and peripapillary atrophy

• Any other disc features

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2
Q

Common disc anomalies not part of disease processes:

A

• Myelinated nerve fibres
• Optic disc drusen
• Tilted optic disc

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3
Q

What are myelinated nerve fibres?

A

• The nerve fires are myelinated within the optic nerve and the myelin sheath usually stops at the lamina cribrosa

• 1% of population
- Unilateral in 80%

• Symptoms:
Usually asymptomatic

• Signs
- Fundus examination: Visible yellow patch of myelin around nerve head
- Visual fields: enlarged blind spot corresponding to area of myelin

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4
Q

What is Optic disc drusen?

A

• Calcified nodules within optic nerve head
0.34% - 2% of population
- Bilateral in 75%

• Unclear pathophysiology - ? Impaired ganglion cell axonal transport
- Buried in childhood, more prominent with age

• Symptoms
- Most Px asymptomatic

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5
Q

Optic disc drusen: Examination

A

• Visual field loss in 75 - 87%
- Enlarged blind spot / arcuate defect
- Remains stable or very slowly progresses

• RAPD
- Possible RAPD if monocular/asymmetric

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6
Q

Optic disc drusen: Optic disc

A

• Appears small in diameter
• Anomalous vascular branching patterns
• Round, whitish, yellow refractile bodies
• Disc may be pale due to RNFL loss

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7
Q

Buried drusen vs swollen disc:

A

• Both may elevate the disc and blur its margins

• Optic disc drusen:
- Lack of hyperaemia
- Lack of microvascular changes
- Normal / atrophic nerve fibre layer
- Anomalous retinal vascular patterns

B-scan
Fluorescein angiography
MRI

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8
Q

Tilted optic disc:

A

• Oblique insertion of optic nerve
• Congenital or associated with myopia

• 1-2% of the population
- 80% bilateral

• Symptoms
- Asymptomatic

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9
Q

Tilted optic disc: Disc

A

• Oval, tilted appearance
• Inferior peripapillary atrophy

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10
Q

What to record when recording posterior pole?

A

• Write which eye
• Vitreous: clear or floaters if present
• Disc: see other slides
• Macula: healthy, comment on pigment if older and abnormalities if present
• Blood vessels:
-pathways and crossings normal
- A:V (measure after 3 anastomoses),
• Periphery: healthy, flat, comment on pigment and abnormalities if present

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11
Q

Tilted optic disc: Visual field

A

• Bitemporal loss
• Superior arcuate scotoma

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12
Q

Define optic neuropathy:

A

• Neuropathy = disease or dysfunction of one or more peripheral nerves
• Damage to the optic nerve due to any cause
• Both swelling and atrophy give signs of optic neuropathy

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13
Q

optic neuropathy: General symptoms

A

• Reduced vision
• Colour vision (possibly on probing)

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14
Q

Time course rules of thumb for optic neuropathies:

A

• Minutes: ischaemic retinal event
• Hours: most commonly ischaemic, more likely optic nerve
• Days-weeks: more frequently inflammation (may reflect ischaemia)
• Months-years: compressive

• Could be overlap

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15
Q

optic neuropathy: Examinations done

A

• Best corrected visual acuity
• Pupillary testing
• Fundus examination
• Visual field testing
• Colour vision
• Contrast sensitivity

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16
Q

optic neuropathy: General signs

A

• VA reduced
• Pupils : RAPD if unilateral/asymmetric
• Fundus exam: Optic disc abnormal or normal
• Visual fields: visual field loss
- Paracentral scotomas, central scotomas
- Arcuate scotomas, broad + nasa defect
- Nasal radiating fibres, temporal wedge
- Blind spot enlargement

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17
Q

Optic neuropathy: Colour vision

A

• Optic neuropathies manifest red-green defects
• Red desaturation, “maroon”
• Optic nerve: dyschromatopsia > visual acuity loss
• Macula: dyschromatopsia = visual acuity loss
• Persisting defect even after visual recovery

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18
Q

Optic Atrophy: describe

A

• Pale (chalky white) disc appearance with sharp margins

• Damage to retinal ganglion cells at any level

• Lesion in optic pathway anterior to lateral geniculate body
- Anterior to chiasm - unilateral;
- Posterior to chiasm - bilateral

• 4-6 weeks to appear from time of axonal damage

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19
Q

Optic Atrophy: Primary vs secondary

A

• Primary Optic Atrophy
No adjacent swelling of ON head

• Secondary Optic Atrophy
Preceded by swelling of ON head

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20
Q

Optic Atrophy: Primary Causes;

A

• Retrobulbar neuritis (inflammation, infection or demyelination affecting optic nerve behind optic disc)
• Compression by tumour or aneurysm
• Hereditary optic neuropathies
• Toxic and nutritional optic neuropathy

21
Q

Optic disc oedema: Describe

A

• Swelling of nonmyelinated nerve fires from impaired axoplasmic
- Evidence of acute/evolving pathology

22
Q

Optic disc oedema: Signs

A

• Elevated appearance of nerve head
• Filling of cup
• Retinal vessels drape over disc margin
• Blurring of margin
• RNFL oedema - greyish appearance that obscures vessels
• Hyperaemia
• Retinal venous dilatation & tortuosity
• Peripapillary haemorrhages, exudates, cotton wool spots

23
Q

Optic disc oedema: Most common causes;

A

• Papilloedema

• Anterior Ischaemic Optic Neuropathy
- Arteritic anterior ischaemic optic neuropathy (AION)
- Non-Arteritic Anterior Ischaemic optic neuropathy (NAION)

• Inflammation / Optic Neuritis (demyelinating, infectious, non-infectious)

24
Q

Optic disc oedema: Papilloedema
Describe

A

• Raised intracranial pressure
• Pressure is transmitted to the optic nerve
• Swelling of the nerve head results
• BILATERAL

25
Optic disc oedema: Papilloedema GH Symptoms
• Occasionally asymptomatic (could be picked up in routine eye exam) • Nausea and vomiting • Deterioration of consciousness • Pulsatile tinnitus • Headaches
26
Optic disc oedema: Papilloedema Symptoms: headaches
• Can be 'muzzy headed' at start, develops into extreme pain, usually presenting at hospital within 6 weeks • Characteristically in morning, waking up px • Generalised or localised • Worse when pressure increases: moving head, bending over, coughing • Very rarely, headache absent
27
Optic disc oedema: Papilloedema Symptoms : Ocular
• Visual symptoms often absent but reduced VA in later stages • Transient visual loss • Horizontal diplopia (6th nerve palsy) • Constriction of visual field • Altered colour perception
28
Optic disc oedema: Papilloedema Management
• Community Optometrist: same day referral to hospital eye service • In hospital eye service: Treatment of cause
29
Anterior Ischaemic Optic Neuropathy (AION): Describe
• Most common optic neuropathy over 50 year olds • Represents ischaemic damage to optic nerve head
30
What are the different types of AAION?
• AAION • NAION
31
Arteritic Anterior Ischaemic Optic Neuropathy (AAION): Describe
• 5-10% of AION cases • Occurs in older patients • Caused by Giant Cell Arteritis (GCA) - Inflammatory and thrombotic occlusion of short posterior ciliary arteries causing optic nerve head infarction
32
Arteritic Anterior Ischaemic Optic Neuropathy (AAION): Systemic Symptoms
• Usually 60-80years old • Tender, hardened, non pulsatile temporal artery Scalp tenderness, especially on brushing hair • Jaw claudication (pain on speaking or chewing, almost pathognomonic) • Proximal muscle weakness (typically shoulders) These may cause: • Reduced appetite • Unexplained weight loss • Unexplained lethargy, malaise, depression
33
Arteritic Anterior Ischaemic Optic Neuropathy (AAION): Visual symptoms
• Sudden, profound, visual loss • Usually unilateral (initially) • May be proceeded by transient visual obsurcations, flashing lights • Periocular pain
34
Arteritic Anterior Ischaemic Optic Neuropathy (AAION): Visual examination
• VA very poor • Pale swollen disc • Cotton wool spots (signifying retinal ischaemia) • Over 1-2 months, swelling resolves leaving optic atrophy
35
Non-Arteritic Anterior Ischaemic Optic Neuropathy (NAION): Describe
• 90% of AION cases • Occlusion of short posterior ciliary arteries causing infarction of optic nerve head • Typically in 55-70yrs (average 60yrs) - younger compared to AAION
36
Non-Arteritic Anterior Ischaemic Optic Neuropathy (NAION): Risk factors
• Structural "crowding" of the disc when cup is small/absent Common modifiable risk factors include: • diabetes • hypertension • high cholesterol • smoking
37
Non-Arteritic Anterior Ischaemic Optic Neuropathy (NAION): Symptoms
• Sudden, painless loss of vision • Unilateral
38
Non-Arteritic Anterior Ischaemic Optic Neuropathy (NAION): Examination
• VA - Moderate to severe reduction in VA in most px - Most px have no further visual loss although in a small number, visual loss continues for about 6 weeks • Visual fields - Commonly inferior altitudinal defect • Dyschromatopsia - Proportional to amount of VA loss
39
Non-Arteritic Anterior Ischaemic Optic Neuropathy (NAION): Fundus exam
• Disc oedema diffuse or segmental • Disc hyperaemic with abnormal appearance of blood vessels on surface • Often few peripapillary flame-shaped haemorrhages • Atrophy within 3 to 8 weeks of onset • Contralateral eye usually small with absent cup; “disc at risk”
40
Anterior ischaemic Optic Neuropathy (AION): management
• Community: immediate (same day) referral to ophthalmologist • Treatment aimed at preventing blindness of 2nd eye
41
Optic neuritis: causes
• Infection of the optic nerve - Caused by local infection e.g. sinus - Following a viral infection e.g. chicken pox - Following an immunisation • Inflammation of the optic nerve (non-infectious) - Sarcoid - Autoimmune • Demyelination of the optic nerve (most common)
42
Optic neuritis: demylination
• Demyelination disrupts nerve conduction within brain, brainstem and spinal chord sparing peripheral nerves • Common causes: - Multiple sclerosis (most common) - Isolated optic neuritis with no other demyelination, but that may subsequently develop
43
Multiple sclerosis: describe, + relationship to optic neuritis
• MS is an inflammatory, demyelinating disease of the central nervous system (CNS) • Multiple exacerbations characterised by variable CNS involvement • Exacerbations are separated in time and anatomical location • Optic neuritis is the presenting feature in15-20% of those with MS • 50% of those with MS will get optic neuritis at some point • If got optic neuritis, the overall 10 year risk of getting MS is 38%
44
Optic neuritis: symptoms
(reminder: optic neuritis is an infection, inflammation or demyelination of the optic nerve) • Monocular visual impairment • Subacute: develops over several days to 2 weeks • Discomfort, exacerbated by eye movements which precedes visual loss in majority of cases • Globe tenderness
45
Optic neuritis: examination
• VA 6/18-6/60 (or worse) • RAPD • Reduced colour vison / red desaturation • Reduced contrast sensitivity • Field defects • Generalised depression • Nerve fibre bundle defects • Central loss
46
Optic neuritis: Fundus examination
• Normal in most cases (retrobulbar neuritis) • Could get swollen disc
47
Optic neuritis: Demyelination
If due to demyelination, may also get: • cranial nerve palzies • gaze palsies •facial nerve palsies • nystagmus
48
Optic disc oedema: management
• Difficult for high street practitioner to determine cause • Due to possible causes, same day (emergency) referral to hospital is likely

(2) Introductory ocular disease (16 decks)

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