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Psych > Opioids > Flashcards

Opioids Flashcards

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1
Q

List the opioid agonists

A 
morphine
hydromorphine
methadone
meperidine
fentanyl
codeine
oxycodone
hydrocodone
propoxyphene
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2
Q

List the mixed agonist/antagonist

A

pentazocine
nalbuphine
buprenorphine
butorphanol

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3
Q

List the opioid antagonists

A

naloxone

naltrexone

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4
Q

When are opioids used in clinical settings?

A 
MI
sickle cell crisis
post operative procedures
trauma
cancer
kidney stones
back pain
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5
Q

SEs of opioids

A

CNS depression
Constipation
hypotension

Black box warning: respiratory depression that can be life-threatening/fatal

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6
Q

Additional indications of opioids

A 
adjunct to general anesthesia
epidural anethesia
palliative care
antitussive
antidiarrheal (loperamide)
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7
Q

mu receptors

A

supraspinal & spinal analgesia; sedation; inhibition of respiration; slowed GI transit; modulation of hormone & neurotransmitter release

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8
Q

delta receptors

A

supraspinal & spinal analgesia; modulation of hormone & neurotransmitter release

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9
Q

kappa receptors

A

supraspinal & spinal analgesia; psychotomimetic effects; slowed GI transit

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10
Q

Methadone is a full agonist at what receptor

A

mu

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11
Q

buprenorphine is a partial agonist at what receptors

A

mu, kappa, delta

used for opioid addiction

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12
Q

naltrexone is an antagonist at what receptor, and a partial agonist at what

A

mu
partial- kappa
used for alcohol & opioid addiction

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13
Q

nalmefene is an antagonist at what and a partial agonist at what

A

mu
kappa
used for alcohol addiction

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14
Q

chronic adverse effects of opioid use

A 
hypogonadism
immunosuppression
increased feeding
increased growth hormone
withdrawal effects
tolerance, dependence
abuse
hyperalgesia
impairment while driving
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15
Q

acute adverse effects of opioid use

A 
resp depression
N/V
pruritus
urticaria
constipation
urinary retention
delirium
sedation
myoclonus
seizures
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16
Q

opioid drug interactions

A

sedative/hypnotics–increased CNS depression
antipsychotic agents– increased sedation, accentuation of CV effects
monoamine oxidase inhibitors– relative contraindations, high incidence of hyper-pyrexic coma

17
Q

What is the most potent opioid

A

fentanyl

18
Q

naloxone indications & warnings

A

used for opioid overdose, reversal of resp depression

warnings: acute opioid withdrawal

19
Q

naltrexone indications & warnings

A

tx of alcohol use disorder
warnings: acute opioid withdrawal & accidental opioid overdose (pts treated with this drug may respond to lower doses of opioid than previously used)

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