Opioids Flashcards
1
Q
Tramadol
A
Prodrug, mu agonist (weak), inhibits re-uptake of serotonin and norepinephrin
2
Q
Buprenorphine
A
MOR = high affinity but partial agonist KOR = antagonist
Good for addiction control
3
Q
Agonist-Antagonists
A
Pentazocine,nalbuphine,butorphanol
Reverse some side effects
4
Q
Antagonists
A
High affinity but no efficacy
Naloxone, Naltrexone
Use these as addiction deterents
5
Q
Antagonists (peripheral)
A
PAMORA –> good for opioid related constipation
Methylnaltrexone (sq), Alvimopan (oral), Naloxegol (oral)
6
Q
Serotonin Receptors
A
1B: vasoconstriction
1D: smooth muscle contraction, agonists subdue inflammatory release
7
Q
Triptans
A
Block vasoconstriction and inflammatory release at trigeminal, suma-SQ is fastest onset
