Opioids

Question 1

Effects of Opioids on CNS

Answer 1

Analgesia
Sedation
Euphoria
Nauses and Vomiting
Pupillary constriction
Respiratory Depression
Depression of vasomotor centre
Addiction

Question 2

Effect of opioids on Urinary tract

Answer 2

Increase sphincter tone

Urinary retention

Question 3

Effect of opioid on respiratory system

Answer 3

Anti-tussive

Bronchospasm in susceptible pts

Question 4

Effect of opioids on Cardiovascular system

Answer 4

Peripheral venodilation

Bradycardia due to vagal stimulation

Question 5

Opioid effect on skin

Answer 5

Itching

Question 6

Effect of opioids on GI tract

Answer 6

Reduced peristalsis - Constipation, delayed gastric emptying

Constriction of sphincters

Question 7

Effects of opioids on endocrine system

Answer 7

Release of ADH and catecholamines

Question 8

Which receptors does tramadol work at?

Answer 8

Weak agonist, predominantly at MOP receptors (mu opioid receptors)

Question 9

What dose of tramadol?

Answer 9

50-100mg QDS orally

Question 10

Indications of Morphine IV

Answer 10

Visceral pain and MI pain,

Less effective in trauma

Question 11

IV morphine dose

Answer 11

0.1-0.15mg/kg

Lasts 45-60 mins

Question 12

IM morphine dose

Answer 12

0.2-0.3mg/kg

Lasts 60-120mins