Opioids

Question 1

Define opioid

Answer 1

-natural and semisynthetic opium alkaloid derivatives, synthetic agents, and other agents who have opioid like effected

Question 2

Endogenous Opioid Peptides

Answer 2

-naturally occurring substances present in the body

Question 3

what is the common amino acid terminal sequence for opioid peptides?

Answer 3

Tyr-Gly-Gly-Phe (Met or Leu)

Question 4

3 major precursor proteins

Answer 4

-prepro-opiomelanocortin (POMC)
-proenkephalin A
-Preprodynorphin (preproenkephalin B)

Question 5

What sequences are in POMC

Answer 5

-Met-enkephalin
-b-endorphin
-ACTH
-B-lipotropin
-MSH

Question 6

What sequences are in preproenkephalin?

Answer 6

-6 copies of met-enkephalin
-one copy of leu-enkephalin

Question 7

What sequences are in preprodynorphin?

Answer 7

-Dynorphin A
-Dynorphin B
- a and b neoendorphin

Question 8

What causes variety of responses to activating receptors?

Answer 8

alternate splice variants for different subtypes

Question 9

Opioid MOA Ascending neuron

Answer 9

-inhibit Ca channels at presynaptic neuron
-promote K channels at post synaptic neuron
-inhibit glutamate or substance P, reducing excitatory pain signaling