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PHRM 845 exam 5 > opioids > Flashcards

opioids Flashcards

1
Q

Codeine (Tylenol #3) formulation

A

tablet, cough syrup

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2
Q

Codeine (Tylenol #3) clinical pearls

A

metabolized to morphine via CYP 2d6
not recommended in breastfeeding and kids under 12

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3
Q

Tramadol (Conzip) formulation

A

capsule ER 24hr, tablet -IR and ER 24hr, oral solution, combination product with acetaminophen and celecoxib available

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4
Q

Tramadol (Conzip) clinical pearls

A

BOX warning: use of CYP3A4 inducer and inhibitor or 2D6 inhibitors request careful consideration
Schedule IV

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5
Q

Morphine formulation

A

capsule ER 24hr, tablet IR and 12hr ER, oral solution, solution for injection, suppository

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6
Q

Morphine clinical pearls

A

itching is prominent side effect
renally excreted
BOX warning: avoid alcohol while taking ER capsule - increases morphine levels

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7
Q

Hydromophone (dilaudid) formulations

A

IR and ER tablet, oral solution, solution for injection, suppository

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8
Q

Hydromophone (dilaudid) clinical pearls

A

US box warning: dose errors when prescribing

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9
Q

Hydrocodone +/- acetaminophen (Norco) formulation

A

oral solution, ER tablet, tablet

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10
Q

Hydrocodone +/- acetaminophen (Norco) dosing and clinical pearl

A

tablet - 5/325, 7.5/325mg, 10/325mg
BOX warning for use of cyp3A4 inhibitors and increase plasma concentration of Norco

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11
Q

0xycodone (oxycotin) (percocet - oxycotin and acetaminophen) formulations

A

Tablet, capsule, oral solution

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12
Q

0xycodone (oxycotin) (percocet - oxycotin and acetaminophen) clinical pearls

A

Box warning for use of cyp3A4 inhbitor and increasing plasma levels of oxycodone

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13
Q

Fentanyl (duragesic) formulations

A

buccal tablet, sublingual liquid, lozenge, injection solution, patch

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14
Q

Fentanyl (duragesic) clinical pearls

A

Box warning for use of cyp3A4 inhbitor and increasing plasma levels of fentanyl
can use in renal impairment
less hypotension than morphine or hydromorphone

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15
Q

Methadone (methadose) formulation

A

oral solution, injectable solution, tablet

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16
Q

Methadone (methadose) use and clinical pearls

A

last line treatment for chronic pain, opioid detoxification
Box warning: QTC prolongation and CYP3A4 interaction

17
Q

Meperidine (demerol) formulation

A

injectable solution, oral solution, tablet

18
Q

Meperidine (demerol) clinical pearls

A

AVOID IN ELDERLY
Box warning do not use withing 14 days of monoamine oxidase inhibitors
Monitor levels due to interaction cyp3A4
metabolized in the liver

PHRM 845 exam 5 (12 decks)

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