Dr.Watts alcohol

Question 1

Fomepizole (antizol)

Answer 1

Works by inhibiting ADH in the cases of overdose due to antifreeze or MeOH poisoning and it will slow down the formation of Formaldehyde which is a toxic chemical

Question 2

Disulfiram (Antabuse)

Answer 2

Irreversible inhibitor of ALDH which means that if a patient were to consume alcohol while on this it would be metabolized to acetaldehyde which causes you to get sick and vomit
used as aversive therapy
effects of the drug last for up to 14 days so even if patient misses a day they will still get sick if they consume alcohol

Question 3

Alcohols action

Answer 3

Main target is GABAa receptor - it is allosteric activator of inhibitory neurotransmitters which means it allows more chloride into the cell making it more negative

Question 4

legal limit

Answer 4

0.8%

Question 5

Side effects of alcohol

Answer 5

Euphoria, talkative, analgesia, aggression, mood swings, CNS depression at high levels

Question 6

Chronic effects of alcohol

Answer 6

cardiomyopathy, arrhythmia, hypertension, hemostasis

Question 7

Drug interactions

Answer 7

CNS depressants
Aldehyde dehydrogenase inhibitors
Acetaminophen
Aspirin

Question 8

Acamprosate (Campral)

Answer 8

NMDA receptor antagonist/ GABA agonist
- some of the same activity of alcohol (replacement therapy)

Question 9

Naltrexone (Revia)

Answer 9

Opioid receptor antagonists
if people drink while taking this medication there is not as much as a reward feeling towards drinking

Question 10

Mutation in Mu receptor

Answer 10

SNP mutation that allows enkephalins to bind more tightly to the receptor and you get more rewarding effects

Patients with this mutation respond better to Naltrexone

Question 11

Baclofen (Baclofen)

Answer 11

good for patients who are having anxiety related to withdrawal of alcohol

NOT FDA APPROVED