Opioids Flashcards by Brooke Katherine

Q

dilaudid onset

A

15 mins

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Q

dilaudid duration

A

2-4 hrs

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Q

dilaudid dose

A

0.01-0.02 mg/kg

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Q

fentanyl onset

A

1-2 min

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Q

fentanyl duration

A

20-40 min

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Q

fentanyl metabolism

A

significant first pass in the lungs

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Q

fentanyl metabolism is dependent on

A

hepatic blood flow

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Q

sufentanil metabolism

A

significant first pass in lungs

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Q

sufentanil dose

A

0.05-0.2 mcg/kg/hr

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Q

when to turn off sufentanil before emergence

A

30 mins prior

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Q

alfentanil onset

A

super fast

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Q

why is alfentanil a fast onset

A

90% non-ionized
low pKa

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Q

alfentanil dose for blunting SNS

A

15mcg/kg

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Q

alfentanil dose gtt

A

25-50 mcg/kg/hr

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Q

alfentanil dose for loss of consciousness

A

150-300 mcg/kg

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Q

alfentanil metabolism

A

liver

Q

alfentanil drug interaction and effect

A

erythromycin- prolongs metabolism and resp. depression

Q

remi metabolism

A

ester link
hydrolyzed by blood and tissue esterases

Q

when to stop remi prior to emergence

A

10 min

Q

remi dose

A

0.05-0.2 mcg/kg/min

Q

methadone MOA

A

opioid receptor agonist and NMDA antagonist

Q

methadone duration and reason

A

24-36 hr
highly protein bound

Q

methadone side effect

A

prolonged QT

Q

tramadol drug interaction

A

SSRIs- serotonin syndrome

Q

tramadol structure

A

synthetic codeine

Q

tramadol MOA

A

stimulated alpha 2

Q

tramadol half life

A

5-6 hrs

Q

tramadol 3 side effects

A

seizures
hypoglycemia
hyponatremia

Q

demerol drug interaction

A

MAOIs- serotonin syndrome

Q

demerol metabolite

A

normeperidine
1/2 potency
lowers seizure threshold

Q

naltrexone duration

A

24 hours

Q

narcan dose

A

0.4 mg

Q

narcan side effect

A

pulm edema

Q

narcan duration

A

less than 1 hr
may need to redose