NMBD Flashcards
Sux TBW vs IBW
TBW
Sux standard intubation dose
1 mg/kg
Sux RSI dose
1.5 mg/kg
Sux duration
9-13 mins
Sux onset
30-90 seconds
Sux elimination half-time
47 seconds
Roc standard intubation dose
0.6-1 mg/kg
Roc RSI dose
1.2 mg/kg
Roc maintenance dose
0.1 mg/kg
Roc onset
45-90 seconds
Roc duration
30-60 mins
Roc TBW vs IBW
IBW
Vec TBW vs IBW
IBW
Vec intubation dose
0.1-0.2 mg/kg
Vec maintenance dose
0.02 mg/kg
Vec onset
2-4 mins
Vec duration
30-45 mins
Pancuronium TBW vs IBW
IBW
Pancuronium intubation dose
0.1-0.15 mg/kg
Pancuronium maintenance dose
0.02 mg/kg
Pancuronium onset
2-4 mins
Pancuronium duration
60-90 mins
Atracurium TBW vs IBW
IBW
Atracurium intubation dose
0.5-0.6 mg/kg
Atracurium maintenance dose
0.1 mg/kg
Atracurium onset
2-3 mins
Atracurium duration
30-60 mins
Cisatracurium TBW vs IBW
IBW
Cisatracurium intubation dose
0.1-0.2 mg/kg
Cisatracurium maintenance dose
0.02 mg/kg
Cisatracurium onset
2.5-3.5 mins
Cisatracurium duration
45-60 mins
Mivacurium TBW vs IBW
IBW
Mivacurium intubation dose
0.15-0.25 mg/kg
Mivacurium maintenance dose
0.1 mg/kg
Mivacurium onset
2-3 mins
Mivacurium duration
15-20 mins
Which NMBD release histamine
mivacurium
atracurium
sux
Which NMBD utilizes hofmann elimination
atracurium
cisatracurium
What is the toxic metabolite produces by hofmann elimination
laudanosine
Order in which volatile anes increase potency of NMBD
Des>Sevo>Iso>Halothane>N2O
Which NMBD is NOT metabolized
Roc
Which NMBDs have active metabolites (not related to hofmann elimination)
Vec
Pancuronium
Which NMBD are at highest risk of anaphylaxis
Roc and sux
Edrophonium MOA
electrostatic attachment
Neostigmine MOA
formation of carbamyl esters
Pyridostigmine MOA
formation of carbamyl esters
Physostigmine MOA
formation of carbamyl esters
Edrophonium dose
0.5-1 mg/kg
Neostigmine dose
0.02-0.07 mg/kg
Pyridostigmine dose
0.1-0.3 mg/kg
Edrophonium onset
1-2 min
Neostigmine onset
5-15 min
Pyridostigmine onset
10-20 min
Edrophonium duration
30-60 min
Neostigmine duration
45-90 min
Pyridostigmine duration
60-120 min
Edrophonium metabolism
Renal 75
Liver 25
Neostigmine metabolism
50/50 renal and liver
Pyridostigmine metabolism
Renal 75
Liver 25
Best pairing for neostigmine
glyco
Best paring for pyridostigmine
glyco
Best pairing for edrophonium
atropine
Which anticholinergic affects HR the most
atropine
Which anticholinergics cross the BBB (2)
scopolamine
atropine
Which anticholinergic does not cross the BBB
glyco
