Opioid Analgesics Flashcards
Gold standard opioid analgesic
Morphine
Active metabolite of morphine and its effects
Morphine-6-glucoronide
Drowsiness
N&V
Coma
Respiratory depression
Ideal for subcutaneous administration
Hydromorphone
Preferred opioid for pts w/ acute pain and impaired kidney function
Hydromorphone
Side effects of hydromorphone 3 glucoronide
Neuroexcitation and cognitive impairment
Suitable for renal failure patients, 80x the potency of morphine
Fentanyl
1000x the potency of morphine
Sufentanil
Assoc w/ opioid induced hyperalgesia
Remifentanil
No role in chronic pain, with neurotoxic metabolite
Contraindicated in pt taking MAOi
Meperidine
Broad spectrum opioid
Methadone
Have a ceiling effect for respiratory depression, anti-inflammatory
Derived from thebaine
Buprenorphine