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Anesthesia Review kat > Neuromuscular > Flashcards

Neuromuscular Flashcards

1
Q

NM disease resistant to depolarizing NMB (sux) snd sensitive to Nondepolarizing muscle relaxant

A

Myesthenia Gravis

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2
Q

Decreased Ach receptors, post junctional

A

MG

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3
Q

Decreased release of Ach (presynaptic) at the myoneural junction
Normal # of Ach receptors

A

LEMS

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4
Q

Sensitive to both depolaring and non depolarizing NMB

A

LEMS

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5
Q

Degenerative CNS disease associated with decreased plasma cholinesterase activity. Prolonged response to Succinylcholine

A

Huntington’s chorea

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6
Q

Class of non depolarizing NMB that has no significant histamine release

A

Aminosteroids (-onium)

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7
Q

Class of Nondepolarizing NMB that cause histamine release

A

Benzylisoquinolinium (-urium)

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8
Q

Drugs that enhance neuromuscular blockade by non depolarizing NMB

A 
Aminoglycosides (streptomycin, genta, tobra, neonycin)
Lincosamides (clindamycin, lincomysin)
Volatile anesthetics
Calcium channel blockers
Magnesium
IV local anesthetics
Furosemide
Dantrolene
Lithium
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9
Q

Conditions with quantitative decrease in pseudocholinesterase/ butyrylcholinesterase

A 
Pregnancy
Burns
Advanced age
Malnutrition
Liver disease
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10
Q

Investigates the QUALITATIVE change in pseudocholinesterase

A

Dibucaine inhibition test

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11
Q

Co- administering these meds can reduce cholinesterase activity which prolongs the effect of succinylcholine

A

Neostigmine
Metoclopramide
Esmolol

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12
Q

Normal dibucaine number

Homozygous typical

A

80

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13
Q

Dibucaine number for heterozygous atypical with a block duration of
20mins

A

50-60

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14
Q

Dibucaine nunber for homozygous atypical with a block duration of 1-3 hrs

A

20-30

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15
Q

Drug contraindicated in acute intermittent porphyria

A 
Etomidate
Barbiturates
Ketorolac
Pentazocine
Phenytoin
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16
Q

Drug contraindicated in Duchenne muscle dystrophy

A

Succinylcholine

17
Q

Efficacy of NM blockade during hypokalemia

A

Resistant to depolarizing NMB

Sensitive to nondepolarizing NMB

Anesthesia Review kat (4 decks)

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