Opioid Anagesics Flashcards
Morphine
Strong agonist opioid
Methadone
Strong agonist opioid
Meperidine
Strong agonist opioid
Fentanyl
Strong agonist opioid
Codeine
Moderate agonist opioid
Oxycodone
Moderate agonist opioid
Tramadol
Weak agonist opioid
Naloxone
Antagonist opioid
Naltrexone
Antagonist opioid
Where are “Opioid receptor”?
Brain,brain stem,spinal cord,peripheral neuron,intestine
PK:absorption
Which drug is effective orally
(Less first pass metabolism)
Codeine oxycodone
Pk:distribution
Highly lipophilic opioid—>สะสมที่fatty tissue
Fentanyl
Pk:distribution
Cross placenta:เกิดอะไรขึ้น
Respiratory deprssion and neonatal dependence
PK:metabolism
Cause seizure at high level
Meperidine
Clinical use
Analgesics
- Relief severe pain
- analgesic supplement in maintenance of general anesthesia