Opioid Anagesics Flashcards
Morphine
Strong agonist opioid
Methadone
Strong agonist opioid
Meperidine
Strong agonist opioid
Fentanyl
Strong agonist opioid
Codeine
Moderate agonist opioid
Oxycodone
Moderate agonist opioid
Tramadol
Weak agonist opioid
Naloxone
Antagonist opioid
Naltrexone
Antagonist opioid
Where are “Opioid receptor”?
Brain,brain stem,spinal cord,peripheral neuron,intestine
PK:absorption
Which drug is effective orally
(Less first pass metabolism)
Codeine oxycodone
Pk:distribution
Highly lipophilic opioid—>สะสมที่fatty tissue
Fentanyl
Pk:distribution
Cross placenta:เกิดอะไรขึ้น
Respiratory deprssion and neonatal dependence
PK:metabolism
Cause seizure at high level
Meperidine
Clinical use
Analgesics
- Relief severe pain
- analgesic supplement in maintenance of general anesthesia
Dextromethorphan
Weak agonist opioid
Relief severe pain associated with trauma,MI or CA
Morphine
Acute pulmonary edema
(Reduce perception of shortness of breath,anxiety,cardiac preload and after load
Morphine
Longer duration of action and milder withdrawal symptoms
เทียบกับ morphine
Methadone
Maintenance therapy of heroin addiction
Methadone
Control of withdrawal symptoms from opioid
Methadone
Neurapathic pain
Methadone
Oral agent for severe pain
Methadone
Not affect uterine contraction in clinical dose
Meperidine
Post administration shivering and shaking chills caused by amphotericainB
Meperidine
Inhibit cough center,respiratory center and increase cough threshold
—>antitussive
Codeine
Dose for antitussive of codeine
15 mg for cough
Analgesic ให้คู่กับ aspirin or acetaminophen
Codeine
ADR:Decrease seizure threshold
Tramadol
Use for acute toxic of opioid
Naloxone(IV)
Clinical use
Sedation and relief from anxiety
Additive with other CNS depressants
