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CNS Stimulant > Opioid Anagesics > Flashcards

Opioid Anagesics Flashcards

1
Q

Morphine

A

Strong agonist opioid

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2
Q

Methadone

A

Strong agonist opioid

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3
Q

Meperidine

A

Strong agonist opioid

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4
Q

Fentanyl

A

Strong agonist opioid

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6
Q

Codeine

A

Moderate agonist opioid

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7
Q

Oxycodone

A

Moderate agonist opioid

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8
Q

Tramadol

A

Weak agonist opioid

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9
Q

Naloxone

A

Antagonist opioid

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10
Q

Naltrexone

A

Antagonist opioid

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11
Q

Where are “Opioid receptor”?

A

Brain,brain stem,spinal cord,peripheral neuron,intestine

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12
Q

PK:absorption
Which drug is effective orally
(Less first pass metabolism)

A

Codeine oxycodone

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13
Q

Pk:distribution

Highly lipophilic opioid—>สะสมที่fatty tissue

A

Fentanyl

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14
Q

Pk:distribution

Cross placenta:เกิดอะไรขึ้น

A

Respiratory deprssion and neonatal dependence

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15
Q

PK:metabolism

Cause seizure at high level

A

Meperidine

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16
Q

Clinical use

Analgesics

A
  • Relief severe pain

- analgesic supplement in maintenance of general anesthesia

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17
Q

Dextromethorphan

A

Weak agonist opioid

18
Q

Relief severe pain associated with trauma,MI or CA

A

Morphine

19
Q

Acute pulmonary edema

(Reduce perception of shortness of breath,anxiety,cardiac preload and after load

A

Morphine

20
Q

Longer duration of action and milder withdrawal symptoms

เทียบกับ morphine

A

Methadone

21
Q

Maintenance therapy of heroin addiction

A

Methadone

22
Q

Control of withdrawal symptoms from opioid

A

Methadone

23
Q

Neurapathic pain

A

Methadone

24
Q

Oral agent for severe pain

A

Methadone

25
Q

Not affect uterine contraction in clinical dose

A

Meperidine

26
Q

Post administration shivering and shaking chills caused by amphotericainB

A

Meperidine

27
Q

Inhibit cough center,respiratory center and increase cough threshold

—>antitussive

A

Codeine

28
Q

Dose for antitussive of codeine

A

15 mg for cough

29
Q

Analgesic ให้คู่กับ aspirin or acetaminophen

A

Codeine

30
Q

ADR:Decrease seizure threshold

A

Tramadol

31
Q

Use for acute toxic of opioid

A

Naloxone(IV)

32
Q

Clinical use

Sedation and relief from anxiety

A

Additive with other CNS depressants

CNS Stimulant (3 decks)

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