Opiods - Compound Preparations Flashcards
1
Q
What are indications for compound opioid use?
A
Mild-to-moderate pain
2
Q
What is the mechanism of action of compound opioids?
A
- Paracetamol - weak inhibitor of cyclooxygenase (COX), which appears to increase the pain threshold.
- Codeine and dihydrocodeine - metabolised by cytochrome P450 enzymes to morphine and morphine-related metabolites. These metabolites, which are agonists of opioid µ-receptors.
3
Q
What are common side effects of compound opioids?
A
- Nausea
- Constipation
- Drowsiness
- Hepatotoxicity
- Neurological and RR
4
Q
What might you want to offer to someone using compound opioids?
A
Laxatives if long term
5
Q
What would you want to communicate to a ptient being given compound opioids?
A
- Avoid driving and heavy machinery if drowsy
- Take no other meds that contain paracetamol
6
Q
What are examples of compound opioids?
A
- Co-codamol
- Co-dydramol
