Aspirin Flashcards

1
Q

What are common indications for using aspirin?

A
  • ACS
  • Acute ischaemic stroke
  • Secondary prevention - CVS, cerebravascular, peripheral arterial disease
  • AF
  • Mild-moderate pain
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2
Q

How does aspirin work?

A

Irreversibly inhibits cyclooxegnase to reduce production of the pro-aggregatory factor thromboxane from arachadonic acid, reducing platelet aggregation and the risk of arterial occlusion

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3
Q

How long does the effect of aspirin last?

A

Lifespan of a platelet - wears off only as new platelets are made

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4
Q

What are adverse effects of aspirin?

A
  • GI irritation
  • GI ulceration
  • Haemorrhage
  • Hypersensitivity reactions - Bronchospasm
  • Tinnitus
  • Overdose
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5
Q

What are features of aspirin overdose?

A
  • Hyperventilation
  • Hearing changes
  • Metabolic acidosis
  • Confusion
  • Convulsions
  • CV collapse
  • Respiratory arrest
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6
Q

When is aspirin contraindicated?

A
  • Children under age of 16
  • Aspirin hypersensitivity
  • Third trimester pregnancy
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7
Q

What conditions is it advised to use aspirin with caution?

A
  • Peptic ulceration
  • Gout - can cause acute attack
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8
Q

Why should you not give aspirin to children under the age of 16?

A

Reye’s syndrome

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9
Q

What drugs can aspirin interact with?

A

Anti-platelet/anti-coagulant drugs

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10
Q

What dose of aspirin is used in MI?

A

300 mg loading dose, followed by 75mg daily

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11
Q

What dose of aspirin is used in ischaemic stroke?

A

300 mg daily for 2 weeks, then switch to 75 mg daily

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12
Q

What dose of aspirin would you give someone as prophylaxis in AF?

A

75 mg daily

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13
Q

What is the maximum dose of aspirin advised in 24 hours?

A

4 grams

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14
Q

What other medication should you consider giving someone taking aspirin long term?

A

Gastroprotection in those at increased risk of GI complications

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15
Q

What are risk factors for GI complications with aspirin use?

A
  • >65 years
  • Previous peptic ulcer
  • Diabetes
  • CVS disease
  • NSAID use
  • Prednisolone
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16
Q

When is it best to take aspirin?

A

After a meal - minimise gastric irritation