Opiods - Compound Preparations Flashcards

1
Q

What are indications for compound opioid use?

A

Mild-to-moderate pain

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2
Q

What is the mechanism of action of compound opioids?

A
  • Paracetamol - weak inhibitor of cyclooxygenase (COX), which appears to increase the pain threshold.
  • Codeine and dihydrocodeine - metabolised by cytochrome P450 enzymes to morphine and morphine-related metabolites. These metabolites, which are agonists of opioid µ-receptors.
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3
Q

What are common side effects of compound opioids?

A
  • Nausea
  • Constipation
  • Drowsiness
  • Hepatotoxicity
  • Neurological and RR
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4
Q

What might you want to offer to someone using compound opioids?

A

Laxatives if long term

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5
Q

What would you want to communicate to a ptient being given compound opioids?

A
  • Avoid driving and heavy machinery if drowsy
  • Take no other meds that contain paracetamol
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6
Q

What are examples of compound opioids?

A
  • Co-codamol
  • Co-dydramol
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