Aspirin Flashcards
What are common indications for using aspirin?
- ACS
- Acute ischaemic stroke
- Secondary prevention - CVS, cerebravascular, peripheral arterial disease
- AF
- Mild-moderate pain
How does aspirin work?
Irreversibly inhibits cyclooxegnase to reduce production of the pro-aggregatory factor thromboxane from arachadonic acid, reducing platelet aggregation and the risk of arterial occlusion
How long does the effect of aspirin last?
Lifespan of a platelet - wears off only as new platelets are made
What are adverse effects of aspirin?
- GI irritation
- GI ulceration
- Haemorrhage
- Hypersensitivity reactions - Bronchospasm
- Tinnitus
- Overdose
What are features of aspirin overdose?
- Hyperventilation
- Hearing changes
- Metabolic acidosis
- Confusion
- Convulsions
- CV collapse
- Respiratory arrest
When is aspirin contraindicated?
- Children under age of 16
- Aspirin hypersensitivity
- Third trimester pregnancy
What conditions is it advised to use aspirin with caution?
- Peptic ulceration
- Gout - can cause acute attack
Why should you not give aspirin to children under the age of 16?
Reye’s syndrome
What drugs can aspirin interact with?
Anti-platelet/anti-coagulant drugs
What dose of aspirin is used in MI?
300 mg loading dose, followed by 75mg daily
What dose of aspirin is used in ischaemic stroke?
300 mg daily for 2 weeks, then switch to 75 mg daily
What dose of aspirin would you give someone as prophylaxis in AF?
75 mg daily
What is the maximum dose of aspirin advised in 24 hours?
4 grams
What other medication should you consider giving someone taking aspirin long term?
Gastroprotection in those at increased risk of GI complications
What are risk factors for GI complications with aspirin use?
- >65 years
- Previous peptic ulcer
- Diabetes
- CVS disease
- NSAID use
- Prednisolone
