Opiods Flashcards
Opiods Potency from greatest to least
SR FAD MD
Sufentanil > Remifentanil > Fentanyl > Alfentanil> Dilaudid > MSO4 > Demerol
Infusion rates range: sufentanil
0.0015 to 0.01 mcg/kg/min
Infusion rates range: fentanyl
0.01 to 0.05 mcg/kg/min
Infusion rates range: remifentanil
0.05 to 0.25 mcg/kg/min
Infusion rates range: alfentanil
0.25 to 0.75 mcg/kg/min
Drug Dosages Meperidine
50 to 100mg IV produces variable degrees of pain relief and is not always effective in patients with severe pain
Drug Dosages Sufentanil
0.1-0.3 mcg/kg
Drug Dosages Remifentanil
1-2 mcg/kg
Drug Dosages Fentanyl
1-3 mcg/kg
Drug Dosages Alfentanil
10-20 mcg/kg
Opiods pK (Onset)/ % Unionized
Alfentanil 6.5 / 89% Remifentanil 7.3 / 58% Morphine 7.9 / 35% Sufentanil 8.0 / 20% fentanyl 8.4 / 8.5% Meperidine 8.5 / 7 %
Elimination 1/2 time
Remifentanil 0.17- 0.33 Alfentanil 1.4 - 1.5 Morphine 1.7- 3.3 Sufentanil 2.2- 4.6 Meperidine 3.5 fentanyl 3.1- 6.6
Protein Binding (DOA)
Morphine 35% Merepidine 70% Fentanyl 84% Alfentanil 92% Sufentanil 93% Remifentanil 66-93%