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Pharmacology > Opiod Analgesics > Flashcards

Opiod Analgesics Flashcards

1
Q

Family receptors and protein coupled of opioids

A

u, k, d ▶️ Gi protein coupled

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2
Q

Mechanism of action of opioids

A
  • Gi coupled proteins in presynaptic ▶️ ⬇️ Ca influx ▶️ ⬇️ P substance (pain neurotransmitter)
  • Gi coupled proteins in postsynaptic ▶️ ⬆️ K influx ▶️ hyperpolarization (⬇️ pain signal)
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3
Q

Important adverse effect of meperidine. Why could it happen?

A 
Serotonin syndrome (also seizures)
Cytochrome P450 ▶️ normeperidine (serotonin uptake inhibitor)
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4
Q

Classic triad of acute opioid toxicity

A

Pinpoint pupils
Respiratory depression
Coma

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5
Q

Treatment opioid withdrawal

A

Supportive
Methadone
Clonidine (⬇️ SANS-like symptoms)

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6
Q

Used for decrease craving for alcohol

A

Naltrexone

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Pharmacology (22 decks)

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