Adrenergic Pharmacology

Question 1

Which family of drugs can blunt or mask hypoglycemia symptoms? In which setting is it important?

Answer 1

• Beta-blockers

- diabetic insulin-dependent patient: may have hypoglycemia and don’t feel tachycardia, tremor, nervousness, sweats

Question 2

Which endogeny compound activates B2 receptors and why?

Answer 2

Epinephrine (via circulatory)

Mostly are not innervated

Question 3

If you suppose a denervation of SANS, what type of agonist is going to work?

Answer 3

Direct agonists

Question 4

Treatment on beta-blocke overdose

Answer 4

Glucagon

*(+) chronotropic, inotropic by glucagon receptor (no B1 agonist) ▶️ G-protein receptor ▶️ adenyl cyclase

Question 5

Drugs with Beta and Alfa-1 antagonism

Answer 5

Carvedilol ▶️ CHF

Labetalol ▶️ hypertensive crisis

Question 6

Which drug must you avoid if suspect cocaine intoxication? Why?

Answer 6

Beta-blockers

Unopposed Alfa-1 activation ▶️ extreme hypertension