Opiod agonists and antagonists

Question 1

Used to counteract the effects of opiods. Whats the caveat?

Answer 1

Naloxone (narcan). Potent blockage of opiate receptors but shorter half-life than opiods so maintain dose until opiod is cleared

Question 2

partial agonist at mu receptors, antagonist at kappa

Answer 2

Buprenorphine (think BU=MU receptor)

Question 3

opiod limited to GI tract

Answer 3

Loperamide

Question 4

Fast acting, uber-potent, short-duration of action with little heart activity make this drug good for surgery

Answer 4

Fentanyl

Question 5

The most commonly prescribed drug (2002-2012) is metabolized how?

Answer 5

Hydrocodone by conjugation

Question 6

Opiod with serous cardiac effects (prolonged QT) if dosed to high or too long term

Answer 6

Methadone

Question 7

weak mu agonist that can still produce depedence

Answer 7

Tramadol

Question 8

Kappa receptor partial agonist, mu receptor antagonist/partial agonist

Answer 8

Pentazocine

Question 9

Pentazocine or Buprenoorphine is more likely to precipitate withdrawl in opiod dependent people.

Answer 9

Pentazocine

Question 10

Contraindications of morphine use

Answer 10

Decreased respiratory reserves (asthma, emphysema, kyphoscoliosis, cor pulmonale), Head injuries, Pregnancy

Question 11

Opiod drug interactions

Answer 11

Any CNS depressant

Question 12

Opiod for mild-moderate pain

Answer 12

Codeine. Used in conjunction with aspirin or acetaminophen for moderate pain.