Ophthalmic Flashcards

1
Q

What is the leading cause of blindness worldwide?

A

Cataracts

- Leading cause of poor vision in the USA

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2
Q

What is the leading cause of new blindness cases among adults 20-74yo?

A

Diabetes

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3
Q

Eyeball

A

Globe

Adult volume = 30mL

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4
Q

Visual Axis

A

Optic axis - imaginary line from cornea midpoint to retina or macula midpoint
Axial length measures the visual axis

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5
Q

Normal Visual Axis Length

A

23-23.5mm

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6
Q

Hyperopia

A

Farsighted

Globe < 22mm long

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7
Q

Myopia

A

Nearsighted
Axial length >24mm

↑risk globe puncture

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8
Q

Anterior Segment

A

Two chambers:

  1. Anterior
    - Behind the cornea
    - Filled w/ aqueous humor produced by ciliary body
  2. Posterior
    - Contains the lens
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9
Q

Posterior Segment

A

Vitreous humor
Retina
Macula
Optic nerve root

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10
Q

Optic Nerve

A

Cranial nerve II
Optic nerve orbital portion 25-30mm long & travels posteriorly w/in the muscle cone
4mm diameter
NOT A TRUE CRANIAL NERVE
Central retinal artery & vein surround the nerve

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11
Q

What is the optic nerve?

A

Outgrowth of the brain
Covered by meninges - pia, arachnoid, dura
Anything injected into the nerve sheath can travel directly to the brain via CSF

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12
Q

Oculomotor Nerve

A

Cranial nerve III
Innervates the superior rectus, inferior rectus, inferior oblique, medial rectus, & levator
1° motor nerve to the extraocular orbit muscles
Sends PSNS fibers to the ciliary ganglion - innervate iris sphincter muscles to cause pupil constriction
SNS motor fibers control pupil dilation

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13
Q

Trochlear Nerve

A

Cranial nerve IV
Provides motor fibers to the superior oblique muscle
Only orbital cranial motor nerve that enters the orbit from outside the muscle cone
Travels in medial direction to innervate the superior oblique muscle

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14
Q

Trigeminal Nerve

A

Cranial nerve V
Sensory & motor
Intracranial portion forms the trigeminal ganglion
- Ophthalmic, maxillary, & mandibular divisions

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15
Q

Ophthalmic Nerve

A

Trigeminal nerve branch
Provides pain, touch, & temperature sensation to the cornea, ciliary body, iris, lacrimal gland, conjunctiva, nasal mucosa, eyelid, eyebrow, forehead, & nose
- Lacrimal, frontal, & nasociliary
Frontal = largest branch
Nasociliary sends nerve fibers medially & to the ciliary ganglion

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16
Q

Maxillary Nerve

A

Trigeminal nerve branch

Provides pain, touch, & temperature sensation to the upper lip, nasal mucosa, & scalp muscles

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17
Q

Abducens Nerve

A

Cranial nerve VI

Motor function to the lateral rectus muscle

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18
Q

Facial Nerve

A

Cranial nerve VII
Provides motor function to the facial muscles
Upper & lower branches
Upper branch innervates the orbicular muscle, superficial facial, & scalp muscles

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19
Q

Vagus Nerve

A

Cranial nerve X
Motor function to the intrinsic muscles in the larynx & heart
PSNS visceral innervation
*Efferent pathway for oculocardiac reflex

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20
Q

Extraocular Muscles

A
  1. Superior rectus - moves the eye upward
  2. Inferior rectus - moves eye downward
  3. Medial rectus - moves eye nasally
  4. Lateral rectus - moves eye laterally
  5. Superior oblique - rotates eye on horizontal axis towards the nose
  6. Inferior oblique - rotates eyeball on horizontal axis temporally
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21
Q

Superior Rectus

A

Cranial nerve III

Supraduction

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22
Q

Inferior Rectus

A

Cranial nerve III

Infraduction

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23
Q

Medial Rectus

A

Cranial nerve III

ADduction

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24
Q

Lateral Rectus

A

Cranial nerve VI

ABduction

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25
Superior Oblique
Cranial nerve IV | Intorsion, depression
26
Inferior Oblique
Cranial nerve III | Extorsion, elevation
27
Normal IOP
10-20mmHg
28
What determines IOP?
Aqueous humor dynamics - balance b/w production & elimination Changes in choroidal blood volume - vascular meshwork in the posterior chamber ↑venous blood pressure Extraocular muscle tone
29
Aqueous Humor
Thin, watery fluid that fills the space in the anterior chamber b/w the cornea & iris - Nourishes the cornea & lens - Gives the anterior eye form & shape Continually produced by the ciliary body (lies behind the iris) Drains out via trabecular meshwork into the aqueous veins & then into orbit veins
30
↑IOP
``` Eyelid muscle contraction Blinking 5mmHg Squinting 26mmHg Cardiovascular or respiratory variables (CVP, ABP, PaCO2) *Laryngoscopy & intubation External pressure Positioning - prone Succinylcholine Topical anticholinergics ```
31
↓IOP
``` Volatile anesthetics IV anesthetics (exception: Ketamine) Non-depolarizing muscle relaxants Benzodiazepines Narcotics ```
32
Succinylcholine
↑IOP 5-10mmHg for 5-10 minutes MOA unclear Result from prolong extraocular muscle contraction? No consistent method to prevent increase Pediatric laryngospasm dose 4mg/kg IM or 1-2mg/kg IV (10mg)
33
Oculocardiac Reflex
Afferent transmission via Trigeminal nerve V Efferent transmission via Vagus nerve X Pull on muscle → bradycardia Causes - pain, pressure, or eyeball manipulation Traction on medial rectus muscle common
34
Oculocardiac Reflex S/S
``` Cardiac dysrhythmias (bradycardia, sinus arrest, V-fib, AV block, ventricular ectopy) Negative inotropy ```
35
During what surgery does the oculocardiac reflex most commonly occur?
Pediatric strabismus surgery
36
Oculocardiac Reflex Treatment
Anticholinergics pre-treatment (?) Stop the stimulus or release pressure Administer Atropine 10mcg/kg or Glycopyrrolate LA infiltration into medial rectus muscle
37
Detached Retina Surgical Repair
Small gas bubble injected into posterior chamber to hold retina in place Sulfur hexafluoride most commonly used - Inert, poorly diffusible gas - Less soluble in blood than nitrogen & N2O - DOA 10 days Bubble expands 2x in 24 hours Discontinue N2O 20 minutes prior to injection to allow washout Avoid N2O 10-14 days after sulfur hexafluoride
38
Echothiophate
``` IRREVERSIBLE cholinesterase inhibitor Glaucoma treatment Systemic absorption → ↓plasma cholinesterase activity Lasts 3-6 weeks after discontinuation Succinylcholine prolonged 20-30 minutes Extend ester local anesthetics duration ```
39
Topical Eye Medications
Enter bloodstream via outer eye membrane & lacrimal apparatus Close eyes 60 seconds after gtt instilled to improve absorption Avoid blinking Block tear outflow canal (place finger over medial canthus)
40
What are the most commonly performed intraocular procedures?
Cataract & vitreoretinal surgeries
41
Ocular Regional Anesthesia
Peribulbar block Retrobulbar block Facial nerve block
42
Peribulbar Block
Inject LA outside the muscle cone Injection above and/or below orbit Provides eye analgesia & akinesia Typically more patchy - requiring additional supplementation throughout the case (request surgeon admin more LA) Relatively low complication rate Safer choice d/t less hemorrhage & central spinal risk
43
Peribulbar Block | Disadvantages
``` ↑volumes injected 6-8mL ↑IOP Slower onset (5-10 minutes) Possible globe perforation Vertical diplopia (myotoxicity from LA) ```
44
Peribulbar Block | Technique
Patient looks straight ahead Avoid vasculature & optic nerve Dull, short-beveled 25-27G 22mm needle Insert needle lateral aspect of the inferotemporal quadrant & superior-nasal ASPIRATE slowly before injection Inject 6mL local anesthetic Lidocaine + Bupivacaine (+/- Epi 1:400,000)
45
Retrobulbar Block
Inject LA inside the muscle cone Provides eye analgesia & akinesia* (better akinesia for surgeon) ↑complication rate as compared to peribulbar block Hemorrhage risk d/t anesthetic injection inside the muscle cone
46
Retrobulbar Block | Technique
Insert 25G needle through lower lid at lateral third junction & medial 2/3 inferior orbital edge Advance 25-35mm (19-31mm safest) toward orbit apex ASPIRATE & inject 2-5mL local anesthetic Lidocaine & Bupivacaine most common
47
Retrobulbar Block | Complications
``` 1:500 blocks Trauma to optic nerve Vision loss *Retrobulbar hemorrhage Globe perforation Oculocardiac reflex Brainstem anesthesia (injection into optic nerve sheath) - Central LA spread to CSF causing hemodynamic instability & respiratory depression w/in 5min IV or intra-arterial injection Seizure Respiratory or cardiac arrest *Usually occur w/in 15 minutes after block ```
48
Retrobulbar Block | Contraindications
Bleeding disorders Anticoagulation Extreme myopia Open eye injury
49
Sub-Tenon (Episcleral) Block
Local anesthetic placed into potential space b/w tenon's capsule & sclera Inferonasal conjunctival fornix most commonly used Direct needle posteriorly following globe curve Superficial injection allows LA to spread circularly around scleral globe portion (3-5mL) Larger volume (8-11mL) allows spread to extraocular muscle sheaths Deep injection - posterior intra & extraconal spaces (2-5mL) most common
50
Facial Nerve Block
Facial nerve periocular branches | Prevent excessive blinking during eye surgery
51
What are indications for general anesthesia?
``` Pediatric patient Uncooperative patient Severe claustrophobia Inability to communicate Inability to lie flat Open-eye injuries Procedures w/ duration > 2 hours ```
52
General Anesthesia | Disadvantages
``` Nausea/vomiting ↑IOP Aspiration Complications 2° to medical problems (i.e. cardiovascular disease) Time $$$ ```
53
Medication Considerations
Synergistic effects Pediatric/elderly dosing Circulation time
54
Intraop Management
``` Block sedation (short-acting agents) Sedation not required w/ adequate block Rotate HOB 90-180° Standard monitors Oculocardiac reflex Temperature Fluids Consider "light" GA w/ stimulation Hypotension Oxygen & cautery → airway fire risk Corneal abrasion risk Retinal artery occlusion ```
55
Postop Management
PONV (especially pediatrics) Postop eye pain unusual - indicates corneal abrasion or acute intraocular HTN (treat w/ Mannitol or Acetazolamide) Elderly patients w/ MI history ↑risk ischemic events even under LA - consider periop β blockers
56
Strabismus
Ocular misalignment Intervention before 4mos to allow normal stereoscopic visual development ↑MH risk associated w/ underlying myopathy Avoid triggers
57
What is the most common ophthalmic condition requiring surgical repair in children?
Strabismus
58
Strabismus Surgical Correction
Lengthens/shortens ocular muscles to straighten eyes & allow binocular vision 30-60 minutes General anesthesia Minimal EBL PONV prevention - hydration, ↓opioids, avoid N2O, Propofol, LA infiltration near extraocular muscle, antiemetics (Decadron 0.1mg/kg or Zofran 0.1mg/kg) Painful procedure - Tylenol 15mg/kg, Toradol 0.5mg/kg, & Fentanyl 1-3mcg/kg
59
Penetrating Eye Injuries
Full stomach precautions Aspiration risk Prevent ↑IOP
60
Open Globe
``` Full-thickness cornea (transparent outer covering) or sclera (white outer covering) defect Emergency surgery w/ GA Succinylcholine risk vs. benefit Laryngoscopy & intubation ↑IOP Antibiotics - Vancomycin & Zosyn ```
61
Aspiration Prevention
Do NOT attempt to evacuate contents w/ NG tube preop Admin Metoclopramide IV, H2 antagonists (Ranitidine), and/or non-particulate antacid prior to induction Do NOT attempt regional anesthesia LA injection ↑IOP Attempt RSI w/ cricoid pressure & avoiding PPV Extubate awake, spontaneously breathing, & head turned to side
62
Prevent ↑IOP | AVOID
``` AVOID direct pressure on eye AVOID Trendelenburg position AVOID regional anesthesia AVOID ↑CVP AVOID drugs ↑IOP AVOID agitation in young children ```
63
Ophthalmic Anesthesia Complications
``` Retrobulbar hemorrhage Globe puncture Optic nerve sheath trauma IV injection Ocular ischemia Extraocular muscle palsy & ptosis Facial nerve blocks Oculocardiac reflex Corneal abrasion Central retinal artery occlusion d/t prolonged pressure ```
64
Complications | Retrobulbar Hemorrhage
Results from trauma to an orbital vessels Moves eyeball forward Venous hemorrhage - slow onset Arterial - rapid onset & pronounced proptosis Treatment: - Digital pressure - Lateral canthotomy (cut lateral canthus) ↑orbital space → place hemostat in temporal direction along lateral canthus 4-6mm & clamp hemostat, use scissors to incise the crush marks left by hemostat, control local bleeding
65
Complications | Globe Puncture
↑IOP caused by injection (sharp or dull needles) Risks include myopic eye, scleral thinning, scleral buckling, & sclera bulging Prevention - avoid supranasal gaze position, direct needle away from globe axis during insertion, insert needle slowly w/ bevel towards globe, never forcefully inject LA, use modified techniques S/S ↑resistance to injection, pupil dilation/ paralysis, ↑IOP, hemorrhage
66
Complications | Optic Nerve Sheath Trauma
Optic nerve sheath surrounds the optic nerve - Outer sheath contains dura mater - Inner sheath consists arachnoid & pia mater Subarachnoid space contains CSF & continuous w/ optic chiasm Dura splits into 2 layers at optic foramen Inner layer forms optic nerve dural covering & forms orbital epidural space *Observe contralateral pupil block Contralateral pupil constricted → dilated after block → assume subarachnoid/subdural injection & prepare for respiratory arrest
67
Complications | Ocular Ischemia
Retinal vascular occlusion or thrombosis reported after ocular blocks ↓pulsatile ocular blood flow after blocks Optic nerve atrophy reported after regional block or GA Transient optic nerve injury symptoms - include contralateral amaurosis or respiratory arrest or vascular occlusion/thrombosis → vision loss
68
Complications | Extraocular Muscle Palsy & Ptosis
Inferior muscle palsy reported after retrobulbar anesthesia Persistent vertical diplopia (double vision) Surgical intervention indicated Prevention - avoid needle contact w/ extraocular muscles, avoid deep orbital penetration, avoid angling needle toward visual globe axis LA myotoxicity may cause postop diplopia and/or ptosis
69
Complications | Facial Nerve Block
Cranial nerve VII Bell's palsy 2° to direct nerve trauma S/S - dysphagia, hoarseness, coughing & respiratory distress Vagus, glossopharyngeal, & spinal accessory nerves close proximity Prevention: - Avoid large volume LA - Avoid Nadbath block technique in certain patients - Airway concerns → intubate
70
Bells Phenomenon
When the eyeballs move upward & outward in response to the eyes being forcefully closed Protective reflex to prevent corneal injury AKA "belling" Requires MAC 1.8 to abolish this reflex
71
Fluorescein
``` EUA Dye used to visualize the retina images & leaks around corneal surgical sites Dose 5-7mg/kg IV push fast (similar to Adenosine) Wear gloves when prepare & admin ```
72
Retinoblastoma
``` Ocular retina cancer 1° affects children < 4yo Tumor present in the eye or bilateral Curable, but ↑risk cancers later in life Monthly check-ups EUA → laser or cryotherapy ```
73
Amblyopia
Lazy eye Children 0-7yo Initial treatment w/ eye patches or dilation drops on the stronger eye to force the weaker eye to work
74
Corneal Transplant Melts
Corneal transplant rejected or suture to the eye has come undone, leaving an opening to the eye General anesthesia LMA or ETT dependent on melt severity Surgical treatment - few sutures or completely remove the original transplant & replace w/ new one
75
Canaliculi Repairs
Inner or outer canthus repair Common in younger children from dog bites or scratches Fairly quick procedure Performed by plastic surgery resident
76
Endopthalmitis
Tissue or fluid infection INSIDE the eyeball Surgery performed after patient not responded to conservative measures → infection now in the vitreous Vitrectomy performed by retina surgeon to remove infected vitreous gel & inject antibiotics into the eye Possible peribulbar block however not effective in severe infections
77
Tetracaine
``` Local anesthetic gtt Numbing eye drops - Eye only holds 0.5mL - Admin 2-6 drops divided in doses 1-2min apart Utilize w/ PRN sedation ```
78
Diamox
Acetazolamide Carbonic anhydrase inhibitor used to lower IOP ↓aqueous humor production in anterior eye Adult dose 150-500mg Mix w/ NS Admin at end procedure IV incompatible w/ Zofran Contraindicated in patients w/ Sulfa allergies