Crisis Scenarios Flashcards

1
Q

Anaphylaxis Patho

A

Type 1 hypersensitivity (immediate) occurs w/in 15-30min after exposure to antigen (latex exposure delayed d/t absorption via skin)
Antigen introduced to helper T cells
Memory B cells prompt IgE production
IgE attached to mast cells & basophils
Antigen enters bloodstream & attaches to IgE antibodies
Mast cell & basophil lysis → histamine & leukotriene release

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2
Q

Anaphylaxis Causes

A
NMBs - Rocuronium & Succinylcholine
Antibiotics
Latex exposure
Medications - Propofol, Heparin & Protamine, Opioids, LAs
Colloids & blood products
Antiseptics
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3
Q

Anaphylaxis S/S

A
Grade 1-4
CV hypotension & tachycardia
Respiratory bronchospasm & pulmonary edema
Integumentary flushing & hives
Inflammation ↑permeability
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4
Q

Anaphylaxis Treatment

A
Discontinue triggering agent
Assessment 
100% FiO2
Fluid administration
Epinephrine 10-100mcg Q2min IV push → infusion
Antihistamine (Benadryl 50mg H1 blocker)
Ranitidine 50mg H2 blocker
Methylprednisolone (Solu-medrol) 100mg corticosteroid
Bronchodilators (β2 agonists)
Nebulized albuterol
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5
Q

Bronchospasm Patho

A

Stimulus
↑afferent to NTS releases glutamate
Vagus nerve excitation
↑ACh release stimulates M2 & M3 receptors → VSMC contraction ↑tone
Severe bronchoconstriction → bronchospasm

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6
Q

Bronchospasm Causes

A

Airway manipulation - induction, emergence, & repositioning
Insufficient anesthesia depth
Anaphylaxis (presents as bronchospasm w/ hypotension)
Medications - Desflurane, AChEi, histamine releasing (Meperidine), β2 adrenergic antagonists, & Hemabate
Cold air
Aspiration

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7
Q

Bronchospasm S/S

A
↑WOB
Wheezing
Prolonged expiration w/ ↓Vt
V/Q mismatch
Shark fin capnograph
↑PIP
Difficult to manually mask-ventilate
Hypotension 
↑pulmonary vascular resistance → R ventricle overload
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8
Q

Bronchospasm Treatment

A

PREVENTION

  • Preop assessment (reactive airway, asthma, COPD, recent URI, smoker)
  • Allergies
  • Aspiration risk
  • Pre-treat
  1. High flow 100% FiO2
  2. Manual ventilation ensure adequate exhalation time (disconnect circuit - hypotension d/t air trapping)
  3. Help!
  4. Assess & remove stimulus
  5. Deepen anesthesia ↑volatile anesthetic or admin Ketamine
  6. Inhaled short-acting β2 adrenergic agonist (Albuterol)
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9
Q

Laryngospasm Patho

A

Bilateral RLN damage - loss intrinsic muscle tone
SLN external branch innervates cricothyroid muscle
Adduction

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10
Q

Laryngospasm Causes

A

Airway manipulation
Noxious stimuli
Inadequate anesthetic depth → laryngeal stim
Secretions on the vocal cords

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11
Q

High Laryngospasm Risk

A
Reactive airway disease
Smokers
Infection, inflammation, exposure to irritants
Airway abnormality
GERD
Surgical procedures

Reduce the risk - deepen anesthesia, avoid Desflurane, postpone surgery, optimize the patient, pre-treat (Albuterol)

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12
Q

Laryngospasm S/S

A

Hypoxia
↓SpO2
Negative pressure pulmonary edema (pink, frothy sputum)
CV effects

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13
Q

Laryngospasm Treatment

A
  1. Help!
  2. Remove stimulus
  3. Admin 100% FiO2
  4. Open & clear airway
  5. Perform jaw thrust
  6. Apply PPV 10-30cmH2O
  7. Deepen anesthesia (↑volatile anesthetic or Propofol bolus)
  8. Admin Succinylcholine 0.1-2mg/kg IV
  9. Mask ventilate & monitor patient

Larson maneuver
- Stylohyoid & mylohyoid elevate the larynx & open the airway w/ inspiration

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14
Q

Negative Pressure Pulmonary Edema Patho

A

Attempted inspiration against occluded airway
↑negative intrathoracic pressure (normal -4cmH2O → -140cmH2O)
↑VR & afterload
↑pulmonary blood volume & PVR
↑hydrostatic pulmonary pressures
Edema

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15
Q

Negative Pressure Pulmonary Edema Causes

A

Strong inspiratory effect against an occluded airway/closed glottis

Adults:

  • Laryngospasm
  • Upper airway tumors
  • Postop vocal cord paralysis
  • Obesity

Pediatrics:

  • Epiglottitis
  • Croup
  • Laryngotracheobronchitis
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16
Q

Negative Pressure Pulmonary Edema S/S

A
Cough & pink frothy sputum
Mechanically ventilated patient
- Difficulty bagging
- ↑airway pressures
Tachypnea
Desaturation
Rales or rhonchi
Tachycardia
Pulmonary infiltrates
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17
Q

Negative Pressure Pulmonary Edema Treatment

A
Elevate HOB
Maintain patent airway
Provide supplemental FiO2
Initiate PPV
Admin steroid & diuretics
Limit fluid intake
Bronchodilator
Obtain/monitor ABGs
Maintain lower Vt & plateau airway pressures
Laryngospasm - perform Larson maneuver
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18
Q

Equipment Malfunction Definition

A

Inability equipment to perform intended function
Contribute to morbidity & mortality
Difficult to manage equipment malfunction in complex environment
Malfunctions = inevitable
Prompt recognition & response to the malfunction

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19
Q

AANA Standards

A

Standard 6 EQUIPMENT

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20
Q

Airway Equipment Malfunction

EXAMPLES

A
ETT cuff rupture
Dysfunctional ETCO2 capnography
Video laryngoscope malfunction
Check equipment before to ensure properly functioning
Back-up equipment available
PREPARATION & VIGILENCE
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21
Q

AGM Equipment Malfunction

A
Disconnection or misconnection
Leaks
Occlusion or obstruction
Failure to initiate ventilation
Pipeline or tank failure
Relief valve malfunction
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22
Q

Power Failure

A
Manually ventilate w/ bag-mask
Auxiliary oxygen
Transition to IV anesthetic (Propofol TIVA)
Use transport monitors
IV infusion pumps back-up battery 4hr
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23
Q

Airway Fire Causes

A

TRIAD:

  1. Oxidizer - oxygen or nitrous oxide
  2. Fuel - alcohol based prep solutions, surgical drapes, sponges, towels, gauze, ETTs & LMAs, organic matter
  3. Ignition - ESUs, lasers, fiber-optic lights
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24
Q

Airway Fire S/S

A

FIRE!
Smell smoke, melted plastic, burning fuels
Flash, smoldering embers, darkened ETT/LMA, breathing circuit w/ soot, orange or red glow to ETT or LMA
Audible pop
Inability to adequately ventilate

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25
Airway Fire Prevention
PREVENTION Silverstein fire risk assessment Laser proof vs. resistant ETT cuff filled w/ saline or methylene blue Fire extinguishing materials available Sterile saline & saline-moistened cotton gauze Minimum oxygen Avoid N2O during high risk procedures Allow preparation solutions adequate drying time Bipolar ESU not monopolar
26
Airway Fire Treatment
1. Remove ETT/LMA, turn off gases, remove flammable material, & pour saline into airway 2. Extinguish burning ETT/LMA in sterile saline basin 3. Resume ventilation w/ 21% 4. Ventilate w/ 100% FiO2 via face mask only when fire extinguished 5. Examine airway & remove residual debris w/ rigid bronchoscope 6. Consider lavage w/ normal saline 7. Re-intubate w/ smaller ETT when indicated 8. Assess thermal trauma extent Post airway fire - 24hr observation - Monitor delayed laryngeal-tracheal edema - Severe airway burns remain intubated & receive humidified FiO2 - Monthly laryngoscopy or bronchoscopy indicated up to 6mos (tracheal stenosis occur months later) - All materials involved should be retained for further investigation - Report to the Joint Commission as sentinel event
27
Malignant Hyperthermia Patho
RYR1 gene located on 19q13.1 chromosome CACNA1S gene Dihydropyridine & ryanodine VGCa2+ channels ↓receptor threshold to release Ca2+ Resistance to feedback mechanisms ↓Ca2+ ion conductance
28
Malignant Hyperthermia Causes
Exposure to volatile anesthetic agents Succinylcholine Stress?
29
Malignant Hyperthermia S/S
``` ↑ETCO2 not responsive to hyperventilation Tachycardia or arrhythmias Rigidity Tachypnea Labile blood pressure ↑temperature Myoglobinuria Skin mottling or cyanosis SaO2 desaturation Metabolic & respiratory acidosis Hyperkalemia ↑creatinine kinase ↑serum & urine myoglobin ```
30
Malignant Hyperthermia Treatment
Discontinue volatile anesthetic or Succinylcholine HELP! Admin Dantrolene 2.5mg/kg Hyperventilate w/ 100% FiO2 Cooling Activated charcoal filters on AGM circuit Antidysrhythmic Monitor & treat ABGs, blood glucose, coags, CK, serum & urine myoglobin, & liver enzymes Maintain adequate urine output
31
Aspiration Patho
Liquid or particulate matter enter tracheobronchial tree R bronchus more susceptible d/t lesser angle & wider 1. Direct chemical damage to epithelium 2. Inflammatory cascade 3. Infectious fluid consolidation in alveoli 4. V/Q mismatch → shunting
32
Aspiration Causes
Anesthesia ↓lower esophageal sphincter tone & loss protective reflexes
33
High Aspiration Risk
``` Uncontrolled GERD Stroke → dysphagia Diabetes (gastroparesis) Morbid obesity ↑abdominal pressure (ascites/edema) Bowel obstruction Pregnancy >13wks Trauma - SNS response impairs gastric emptying (blood diverts to vital organs) ```
34
Aspiration S/S
Oral secretions - Cough - Mild tracheal irritation - Transient laryngospasm Acidic gastric contents - Arterial hypoxemia - Bronchospasm - Dyspnea - Abnormal breath sounds - ARDS
35
Aspiration Treatment
``` PREVENTION Preop assessment to identify at risk patients NPO guidelines Pharmacologic prophylaxis Gastric U/S RSI ``` Vigilance Trendelenburg Suction mouth & pharynx Intubate & oxygenate ``` Post-aspiration Monitor S/S Cough or wheeze Maintain SpO2 CXR Extended LOS ICU admission ```
36
Myocardial Infarction Patho
``` Atherosclerotic disease NSTEMI vs. STEMI Demand ischemia (supply vs. demand) Supply: - CorrPP - ADBP - LVEDP - HR (diastole time) - Coronary artery resistance Demand: - HR - Preload - Afterload - Contractility/inotropy ```
37
Myocardial Infarction Causes
Supply/demand mismatch
38
Myocardial Infarction S/S
``` Sustained tachycardia or bradycardia Hypertension or hypotension Arterial hypoxemia ST depression or elevation Troponin levels ↑PAOP TEE ventricular wall changes ``` Presentation/sensation potentially masked by anesthetics & other drugs
39
Myocardial Infarction Treatment
PREVENTION = key STEMI - TPA fibrinolytic therapy - Percutaneous coronary intervention - Coronary artery bypass graft Goal re-establish blocked coronary blood flow ↓MVO2 Bed rest, analgesia, supplemental oxygen, β blocker therapy, IV nitroglycerin (short-acting vasodilator), antiplatelets/anticoagulants, ACE inhibitors, ANG II receptor blockers, Ca2+ channel blockers
40
Hemorrhage Patho
Excessive blood loss ↓CO → baroreflex SNS response ↑HR ↑renin, ANG II, vasopressin RAAS activation
41
Hemorrhage Causes
Risk factors include anticoagulants, coagulopathies, certain surgeries, tissue/collagen disorders Incompetent surgeons
42
Hemorrhage S/S
``` Hypotension Acute blood loss & hemodynamic instability Tachycardia ↑HR RAAS activation Na+/H2O retention MAP <50mmHg → CNS ischemic response "Oh shit" "Call vascular surgery" *Suction* ```
43
Hemorrhage Treatment
Phase I - immediate life-threatening & uncontrolled hemorrhage → activate MTP Massive transfusion protocol Phase II - ongoing hemorrhage → tailored management Phase III - controlled hemorrhage → restore physiology
44
Massive Transfusion Protocol
``` 10 units PRBCs in 24hr Goal = maintain end organ perfusion Control airway 100% FiO2 Large bore IVs Blood warmer & rapid infuser Send type & screen IV fluids, Trendelenburg, vasopressors Ideal ratio PRBC:FFP:Platelets 1:1:1 Minimize lethal triad - metabolic acidosis, hypothermia, & coagulopathy ```
45
Thyrotoxicosis Patho
Thyroid gland hyperactivity = hyperthyroidism Thyroid hormones directly excite the heart ↑HR/inotropy Heart muscle strength impaired d/t protein catabolism ↑β adrenergic receptor Upregulation - exaggerated response to circulating catecholamines
46
Thyrotoxicosis Causes
Grave's disease - Autoimmune disorder antibodies bind to TSH receptor & stimulate the thyroid Toxic nodular hyperthyroidism Thyroiditis - release stored thyroid hormones Thyroid cancer
47
Thyrotoxicosis S/S
``` Weight loss Anxiety Fatigue Heat intolerance ↑oxygen consumption ↑SBP 10-15mmHg ↓DBP Vasodilation Sinus tachycardia Cardiac dysrhythmias ↑CO Muscle weakness Hand tremor Difficulty sleeping ```
48
Thyrotoxicosis Treatment
Thyroid gland ablation w/ radioactive iodine Thyroidectomy Anti-thyroid drugs - Thionamides (Methimazole, Carbimazole, Propylthiouracil) β adrenergic blockade - Propranolol, Metoprolol, Atenolol High relapse rate in patients treated only w/ medications
49
Thyroid Storm Patho
Precipitating event rapid ↑thyroid hormone & SNS activity Hypothesized Acute stress or infection causes ↑SNS response & ↑thyroid hormone sensitivity → cytokine release & other immune dysfunction (immunological disturbances)
50
Thyroid Storm Causes
Surgery Abrupt anti-thyroid medication discontinue Trauma Acute illness Parturition Recent use iodinated contrast or radio-iodine therapy Burns Medication SE (amiodarone, anesthetics, salicylates)
51
Thyroid Storm S/S
``` Fever >38.5°C Tachycardia/dysrhythmias Heart failure Hypertension N/V Confusion/agitation Weakness Tremor ```
52
Thyroid Storm Treatment
Identification β adrenergics blunt response Anti-thyroid medications inhibit thyroid hormone synthesis Supportive measures - IVF replacement, electrolyte imbalance correction, reverse any acid-base imbalance, ensure adequate oxygenation ↑FiO2 demand Manage hyperthermia Vasoactive medications & advanced monitoring often necessary
53
Postop Residual NMB Patho
Inadequate neuromuscular blocker reversal | nAChR antagonist
54
Postop Residual NMB Causes
Incomplete relaxant reversal or failure to reverse NMB post-procedure
55
Postop Residual NMB Risk Factors
``` Long-acting NMB Improper dose or timing r/t paralytic or reversal dose Deeper block = higher risk Inhalational agents ↑risk Elderly Longer surgeries Medical conditions: - Renal or liver dysfunction/failure - Neuromuscular disorders - Sepsis or trauma - Adrenocortical dysfunction - Cholinesterase deficiency or genetic variation - Metabolic disturbances - Electrolyte abnormalities - Obesity Medications: - Antibiotics - Antidysrhythmics - Antihypertensives ```
56
Postop Residual NMB S/S
``` Postop pulmonary complications - Hypoxemia - Upper airway muscle weakness or obstruction - Aspiration risk Generalized muscle weakness - Facial weakness - Numbness - Difficulty speaking, coughing, drinking - Inability to perform deep breathing - ↓ventilatory response to hypoxia Awareness during emergence ```
57
Postop Residual NMB Treatment
Peripheral nerve stimulator - Ensure proper placement (stimulate the nerve NOT the muscle) - Avoid monitoring facial muscles (overestimates recovery) Quantitative TOF <0.9 objective measurement
58
Epinephrine
IV concentration 1:10,000 or 0.1mg/mL = 1mg/10mL IM concentration 1:1,000 or 1mg/mL Bronchospasm 10-100mcg Anaphylaxis 10-100mcg IV Q2min → Epi infusion (stabilizes the mast cells) Code dose = 1mg Pediatrics 1-10mcg/kg
59
Don't Forget
``` Call for help! 100% FiO2 Discontinue anesthetics Verbalize differentials Notify the surgical team DELEGATE ```
60
Assess Potential ETT Issues
Displacement Obstruction ↑peak airway pressures d/t secretions or kinked ETT/tubing Pneumothorax Equipment failure
61
Refractory Bronchospasm Treatment
- Epi 10-20mcg - Terbutaline 0.25mg - Intubate - Methylprednisolone 125mg - Inhaled muscarinic antagonist (Ipratropium) - Magnesium sulfate 2g over 15-20min
62
Hemorrhage Class I
<15% blood volume | - No significant vital sign changes
63
Hemorrhage Class II
15-30% - Tachycardia, tachypnea, ↑pulse pressure - Loss 20% ↓BP
64
Hemorrhage Class III
30-40% | - Tachycardia, tachypnea, systolic hypotension, oliguria, mental status changes
65
Hemorrhage Class IVa
>40% - Immediately life-threatening - Severe sustained hypotension, tachycardia, narrow pulse pressure, no UOP, cold & pale skin, ↓mental status
66
Massive Transfusion Protocol | Complications
- Hyperkalemia → arrhythmias or sudden cardiac arrest - Hypocalcemia → muscle weakness, tetany, myocardial dysfunction, coagulopathy - Hypothermia → coagulopathy, arrhythmias, hepatic dysfunction, myocardial depression, ↓drug metabolism