Ondansetron (Zofran®) Flashcards
1
Q
Zofran Drug Classification
A
Antiemetic
2
Q
Zofran Mechanism of Action
A
5-HT3 (serotonin) R antagonist –> blocks serotonin binding to receptors at vagal nerve terminals –> inhibits vomiting reflex
3
Q
Zofran Onset of Action
A
Rapid
4
Q
Zofran Peak Effects
A
15 - 30 minutes
5
Q
Zofran Duration of Effect
A
4 - 8 hours
6
Q
Zofran Half-Life
A
4 hours
7
Q
Zofran Indications / Field Use
A
Nausea / Vomiting
8
Q
Zofran Contraindications
A
Hypersensitivity
9
Q
Zofran Side Effects / Adverse Reactions
A
Headache, dizziness, tachycardia, prolonged QT interval
10
Q
Zofran Dosing: (ADULT)
A
4 mg slow IV/IO, may repeat once
11
Q
Zofran Dosing: (PEDI)
A
0.1 mg/kg (max 4 mg) slow IV/IO
12
Q
Zofran Precautions
A
Lower risk of sedation and dystonia than other anti-emetics
13
Q
Zofran Drug-Drug Interactions
A
Few in EMS
