Morphine Sulfate

Question 1

Morphine Drug Classification

Answer 1

Opiate analgesic

Question 2

Morphine Mechanism of Action

Answer 2

Opiate R agonist –> hyperpolarization of interneurons and decreased release of neurotransmitters responsible for the transmission of pain impulses to the thalamus and cerebral cortex

Question 3

Morphine Onset of Action

Answer 3

Immediate IV, 15 - 30 minutes IM

Question 4

Morphine Peak Effects

Answer 4

20 minutes IV, 30 - 60 minutes IM

Question 5

Morphine Duration of Effect

Answer 5

2 - 7 hours

Question 6

Morphine Half-Life

Answer 6

1 - 7 hours

Question 7

Morphine Indications / Field Use

Answer 7

Severe pain

Question 8

Morphine Contraindications

Answer 8

Hypotension, significant head trauma with AMS

Question 9

Morphine Side Effects / Adverse Reactions

Answer 9

N+V, abdominal cramps, blurred vision, constricted pupils, AMS, headache

Question 10

Morphine Dosing: (ADULT)

Answer 10

0.1 mg/kg slow (2 mg/min) IV/IO/IM, max single dose 10mg, q 10 min up to 3 total doses

Question 11

Morphine Dosing: (ADULT > 65 years)

Answer 11

0.05 mg/kg slow (2 mg/min) IV/IO/IM, max single dose 10mg, q 10 min up to 3 total doses

Question 12

Morphine Dosing: (PEDI)

Answer 12

0.1 mg/kg slow IV/IO/IM

Question 13

Morphine Precautions

Answer 13

Morphine causes reduced chemoreceptor responsiveness to increases in CO2 – may lead to respiratory depression; caution in patients with hypersensitivity to analogs of morphine.

Question 14

Morphine Drug-Drug Interactions

Answer 14

Additive effects (CNS depression) when given with antihistamines, antiemetics, sedatives, hypnotics, barbiturates, and alcohol.