Ondansetron

Question 1

Ondans - mode of action

Answer 1

Anti emetic - 5HT3 (serotonin) antagonist - serotonin thought to trigger vomit reflex

Question 2

Ondans - indications

Answer 2

1. Undifferentiated nausea and vomiting
2. Prophylaxis

Question 3

Ondans - contraindications

Answer 3

1. current apomorphine use

Question 4

Ondans - why is apomorphine a contraindication

Answer 4

Apomorphine is used to treat Parkinson’s disease - reports of profound hypotension and loss of consciousness with ondans

Question 5

Ondans - precautions

Answer 5

1. 1st trimester pregnancy
2. Long QT syndrome
3. Severe hepatic disease
4. Pts with phenylketonuria - ondans contains aspartame

Question 6

Ondans - side effects

Answer 6

1. Headache
2. Dizzy
3. Visual disturbances
4. Constipation
5. QT prolongation

Question 7

Onsans - why is aspartme a contraindication

Answer 7

phenylketonuria is a birth defect that causes a build up of phenylalanine which is toxic to the body - onsans contains aspartame which is an artificial sweetener and is converted into phenylalanine