Oncotype Dx

Question 1

What is oncotype dx?

Answer 1

Multigene assay - 21 genes from a tumour specimen
Predicts 10 year distant recurrence risk
Predicts likelihood of adjuvant chemo benefit
In er +ve breast cancer

Question 2

What is the RS?

Answer 2

Gene expression results combined into a single score of 0-100

Corresponds to a point estimate of 10 year risk of distant recurrence

Question 3

What is high RS and what is recommended

Answer 3

High RS - >25

Substantial benefit from chemo - also give endocrine

Question 4

What is low RS and what is recommended?

Answer 4

Low RS is <11
Minimal benefit from chemo
Endocrine alone

Question 5

Intermediate group RS group

Answer 5

RS score 11-25

What tailorx investigated

Question 6

Who was allowed into tailor x?

Answer 6

HR +ve
HER2 -ve
Axillary node -ve

Question 7

What did tailorx do and what were the results

Answer 7

Randomised intermediate risk scores 11-25 to endocrine alone vs endo and chemo
Looked at 5 year invasive disease free survival (%) - endocrine alone non-inferior 92.8% (+chemo 93.1%) and 5 year OS 98%