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Therapeutics IV > Oncology side effects > Flashcards

Oncology side effects Flashcards

1
Q

Erlotinib/Gefitinib

A

Fatigue, rash(good), diarrhea

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2
Q

Lapatinib

A

CHF, N/V/D

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3
Q

Imatinib

A

N/V, edema, neutropenia/thrombocytopenia

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4
Q

Vemurafenib

A

arthralgias, skin lesions

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5
Q

Trametinib

A

rash, diarrhea, lymphedema

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6
Q

CDK4/6

A

fatigue, N/V, neutropenia

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7
Q

Antimetabolites (in general)

A

myelosuppression

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8
Q

Anthracyclines

A

Cardiotoxicity

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9
Q

Which anthracycline has the worst cardiotoxicity?

A

Daunorubicin

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10
Q

Bleomycin

A

Pulmonary toxicity

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11
Q

Vinca alkaloids

A

Peripheral neuropathy and myelosuppression

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12
Q

Which vinka alkaloid has dose-limiting neurotoxicity?

A

Vincristine

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13
Q

Erubulin

A

Low neurotoxicity (compared to vinka alkyloids)

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14
Q

Taxanes

A

Myelosuppression & neurotoxicity

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15
Q

Epothilones

A

Neurotoxicty

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16
Q

Alkylating agents (in general)

A

Second malignancies; N/V, myelosuppression

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17
Q

Cyclophosphamide

A

Hemorrhagic cystitis

Less bone marrow toxicity

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18
Q

Ifosfamide

A

Hemorrhagic cystitis

CNS toxicity

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19
Q

Nitrosoureas

A

Delayed myelosuppression

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20
Q

Busulfan

A

Pulmonary fibrosis

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21
Q

Dacarbazine

A

Mild bone marrow toxicity

Severe N/V

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22
Q

Cisplatin

A 
Nephrotoxicitiy (dose-limiting)
ototoxicity
Neuropathy
N/V
Minimal myelosuppression
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23
Q

Carboplatin

A

Bone marrow suppression

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24
Q

Oxaliplatin

A

Sensory neuropathy

25
Q

Trastuzumab

A

Flu-like symptoms
CHF
Hypersensitivity

26
Q

Cetuximab

A

Severe infusion reaction
Rash (good)
asthenias
Fever

27
Q

Panitumumab

A

Rash, diarrhhea

NO infusion reaction

28
Q

Rituximab

A

Flu-like symptoms
Mucocutaneous reactions
Lymphopenia
Hypersensitivity reactions

29
Q

Bevacizumab

A

Hemorrhages
DVT
GI perforations
Wound healing

30
Q

TDMI

A

Thrombocytopenia
Hepatotoxicity
Herceptin ADEs

31
Q

Ipilimumab

A

Inflammation (GI, dermatitis, neuropathy)

32
Q

Sipuleucel T

A

Flu-like symptoms, stroke (maybe)

33
Q

Interleukin

A

Fever, malaise, anorexia, fatigue

34
Q

Interferon - alpha

A

Flu-like symptoms, weight loss, fatigue

35
Q

Romidepsin

A

Infections

36
Q

Belinostat

A

N/V, fatigue, anemia

37
Q

Azacytidine

A

Myelosuppression

38
Q

Thalidomide

A

Teratogen
Neuropahty
Fatigue
DVT

39
Q

Lenalidomide

A

TLS
Tumor flare
Hepatotxicity
SPM

40
Q

Bortezomib

A

Neuropathy

41
Q

Omacetaxine

A

Myelosuppression
N/v/d
fatigue

42
Q

Asparaginase

A

Hypersensitivity

NO bone marrow suppression!

43
Q

Exemastane

A

Hot flashes
edema/fluid retention
Increased cholesterol

44
Q

Letrozole/anastrozole

A

Hot flashes
Bone resorption (Fracutres)
Asthenia
bone/join/muscle pain

45
Q

SERM

A

Blood clots
Bone saving
hot flashes
Endometrial cancer

46
Q

SERD

A

Hot flashes

47
Q

Leuprolide/Geneserolide (F)

A

Hot flashes
Sexual dysfunction
Tumor flare

48
Q

Leuprolide/geneserolide (M)

A

Gynecomastia
Sexual dysfunction
Tumor flare

49
Q

Abarerlix/degarelix

A

Gynecomastia

Sexual dysfunction

50
Q

Tamoxifen metabolism

A

CYP2D6 (activating)

51
Q

Panitmumab/cetuximab gene

A

KRAS - must be negative for mutations

52
Q

5-FU metabolism

A

DPD

53
Q

6-MP metabolism

A

TPMT

54
Q

6-TG metabolism

A

TPMT

55
Q

Osimertinib mutation

A

T790M

56
Q

Sorafenib mutation

A

BRAF

57
Q

Vemurafenib/dabrafenib mutation

A

BRAF V600M

58
Q

Irinotecan metabolism

A

UGT1A1

59
Q

Ponatinib mutation

A

T315I

Therapeutics IV (5 decks)

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