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Oncology > Oncology Letters and Numbers > Flashcards

Oncology Letters and Numbers Flashcards

1
Q

Chro 17q mutation

A

BRCA1: dsDNA repair

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2
Q

Chro 13q mutation

A

BRCA2: dsDNA repair

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3
Q

Chro 17 EGFR overexpression

A

HER2

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4
Q

E-Cadherin +

A

Invasive Ductal Carcinoma

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5
Q

E-Cadherin -

A

Lobar Carcinoma

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6
Q

p53 inactive, kras active, EGFR mutation (activates kras), EML4&ALK Chimera

A

Lung Cancer

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7
Q

AK53

A

colon cancer (inactivates APC)

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8
Q

APC

A

colon cancer (inactivates APC)

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9
Q

Wnt

A

colon cancer (how APC blocks growth)

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10
Q

MLH1 & 2

A

decreased in lynch

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11
Q

BRAF mutation

A

lynch

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12
Q

MiB1/Ki67+

A

adenomatous polyp (proliferation)

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13
Q

p16/CDKN2a

A

Pancreatic ductal adenocarcinoma (leads to TP53, SMAD)

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14
Q

TP53

A

pancreatic ductal adenocarcinoma

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15
Q

SMAD4

A

pancreatic ductal adenocarcinoma

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16
Q

hMLH1

A

pancreatic ductal adenocarcinoma (familial, 5%)

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17
Q

hSMH2

A

pancreatic ductal adenocarcinoma (familial, 5%)

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18
Q

CDH1/E-cadherin mutations

A

diffuse gastric cancer (AD inheritance)

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19
Q

E6

A

degrades p53 (HPV16,18)

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20
Q

E7

A

increases DNA synth (HPV16, 18)

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21
Q

16, 18, 6, 11

A

Gardasil HPV strains

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22
Q

MLH1, MSH2/6. PMS2, PTEN

A

uterine cancer (HNPCC/Lynch, p53 loss etc)

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23
Q

LDH

A

dysgerminoma (uterine germ cell)

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24
Q

hCG

A

choriocarcinoma (uterine germ cell)

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25
Q

AFP

A

yolk sac tumor (uterine germ cell)

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26
Q

VHL mutation

A

clear cell renal carcinoma

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27
Q

HPRC (MET path) or HGLRCC

A

papillary renal cell carcinoma

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28
Q

HIF

A

almost all renal cell carcinoma

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29
Q

Chr 3p loss

A

clear cell renal carcinoma (VHL)

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30
Q

Chro 7 & 17 trisomy

A

papillary renal cell carcinoma (HPRC/HGLRCC)

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31
Q

loss of chro 1,6,19

A

chromophobe RCC (best prog)

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32
Q

LOF in Wt1 (11p13)

A

wilms tumor/nephroblastoma (from denys-drash or mutation)

33
Q

increased APF and/or betaHCG +/- LDH

A

Non-seminomatous testicular cancer

34
Q

increased betaHCG +/- LDH

A

seminomatous testicular cancer

35
Q

Loss of GSTP1

A

PTEN/p53/Rb/Myc loss (testicular cancer

36
Q

loss of p16

A

squamous cell carcinoma

37
Q

p16 overexpression

A

HPV SCC (nonkeratinizing, better prog)

38
Q

EWS-FLI1

A

ewings sarcoma, tx chemo

39
Q

C-KIT mutation

A

GI stromal tumor, tx imatinib

40
Q

T(8;21)(15;17), inv(16)

A

good AML prog

41
Q

5q, chemo, complex karyotype

A

bad AML prog

42
Q

T(15;17), PML/RARa fusion transcript

A

APL (AML M3)

43
Q

Tdt+, Ig+, CD10+

A

B-cell ALL

44
Q

Tdt+, CD2+, CD3+

A

T-cell ALL

45
Q

T(9;22)

A

philly! Bad ALL (>60)

46
Q

T(4;11)

A

bad ALL (<1)

47
Q

del (5q31) leads to del (RPS14)

A

5q (MDS subtype)

48
Q

JAK2V617F

A

polycythemia vera (92%)

49
Q

JAK2 mut

A

essential thrombocytosis (42%)

50
Q

CALR better prog than JAK2

A

primary myelofibrosis

51
Q

MR3 (major) >3 log BCR-ABL reduction, MR4.5 (complete) >4.5

52
Q

T(9;22) BCR-ABL fusion

A

CML (increased TK activity)

53
Q

CD20+***, CD5+

54
Q

13q-

A

good CLL prog (-13q14 is intermediate MM)

55
Q

11q-, 17p-

A

Bad CLL prog

56
Q

CD19+, CD20+, CD10+, BC16+ (germinal center markers)

57
Q

BCL6 overexpression

A

GC type DLBCL

58
Q

NFkP addition

A

Non-GC DLBCL

59
Q

CD30 mutation

A

Type 3 (primary mediastinal) BCL

60
Q

IgM, CD19+, CD20+, CD10+, BC16+ (germinal center markers), NEVER Bcl12

A

burkitt’s lymphoma

61
Q

C-myc translocation from t(8;14), t (8;22) or t(2;8)

A

+EBV! Burkitt’s lymphoma

62
Q

CD5+, Cyclin D1+

A

mantle zone lymphoma

63
Q

transloaction of cyclin D1 (11) and heavy-chain Ig (14)

A

mantle zone lymphoma

64
Q

Ki67

A

levels=prog for mantle cell (blastic is worst, leukemic is best)

65
Q

CD19+, CD20+, but no CD10

A

MALT (extra-nodal marginal zone lymphoma)

66
Q

increased NfkB

A

MALT (extra-nodal marginal zone lymphoma)

67
Q

ALK+

A

good prog in Anaplastic Large Cell lymphome

68
Q

CD30+

A

Anaplastic Large Cell Lymphoma, tx: brentuximab

69
Q

T(2;5) mutation

A

younger better Anaplastic Large Cell Lymphoma

70
Q

Bc16, CD10, but NO CD2,3,5,7

A

Angioblastic T-Cell Lymphoma

71
Q

Coombs- anemia, gamma/delta TCR rearrangement

A

hepatosplenic t-cell lymphoma

72
Q

alpha/beta TCR rearrangement, CD3, CD8, NO NKs (CD56-)

A

subcutaneous panniculitis-like lymphoma

73
Q

TAX+. CD4+, CD25+

A

Adult T-cell Lymphoma (HTLV1)

74
Q

HTLV-1

A

virus, causes Adult T-cell lymphoma (Caribbean)

75
Q

PAX+, CD15+, CD30+

76
Q

CD20+, CD30(=)

A

+cervical LAD! Lymph-prominent Hodgkins

77
Q

CD38+ (kappa/gamma restricted)

A

+Mott, Dutcher: MM

78
Q

T(4;14)(p16;q32), t(14;16)(q32;q23), and -p53 (-17p13)

A

Bad MM prog

79
Q

13q14 deletion

A

intermediate MM prog (13- is good CLL)

Oncology (5 decks)

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