Oncology

Question 1

Mazabraud’s syndrome

Answer 1

multiple intramuscular myxomas associated with monostotic or polyostotic fibrous dysplasia

Question 2

t(12;16)

Answer 2

myxoid liposarcoma

Question 3

t(17;22)

Answer 3

dermatofibrosarcoma protuberans

codes for PDGF beta chain/collage type 1 alpha 1 fusion protein

Question 4

Inhibits PDGF receptor tyrosine kinase

Answer 4

imatinib

used in dermatofibrosarcoma protuberans in particular t(17;22) mutation

Question 5

estrogen receptor beta positive

Answer 5

desmoid tumor

Question 6

t(2;13)

Answer 6

alveolar rhabdomyosarcoma

Question 7

Pax3-FKHR fusion protein

Answer 7

alveolar rhabdomyosarcoma

Question 8

small round blue cell tumors of children

Answer 8

1. neuroblastoma (rosette pattern)
2. rhabomyosarc
3. non hodgkin lymphoma
4. Ewing’s sarc
5. blastemic component of Wilm’s tumor
6. Mesenchymal chondrosarc

Question 9

MyoD1 positive
myoglobin positive 
myosin positive
desmin positive
vimentin positive

Answer 9

rhabdomyosarcoma

Question 10

actin and vimentin immunoreactivity

cigar shaped cells on histo

Answer 10

leiomyosarcoma

Question 11

arise in nonmyelinating Schwann cells with biallelic inactivation of NF1 tumor-suppressor gene

Answer 11

neurofibroma

Question 12

loss of neurofibromin leads to increased of what?

Answer 12

increased RAS activity

affects RAS dependent MAPK activity which is essential for osteoclast function and survival

Question 13

positive S100 stain
keratin staining is negative

bag of worms transformation

Answer 13

Malignant peripheral nerve sheath tumor

Question 14

Verocay bodies

Answer 14

Neurolemomma (Schwanoma)

composed of two rows of aligned nuclei in a palisading formation

Antoni A - spindle cells
Antoni B - less cellularity

Question 15

most common sarcoma of the foot

Answer 15

synovial sarcoma

lung most common site of mets.

Rare in that it does metatasize to lymph nodes (SCARE)

Question 16

t(X;18)

Answer 16

synovial sarcoma

Question 17

SYT-SSX1

Answer 17

synovial sarcoma

better survival with SYT-SSX2

Question 18

vimentin
epithelial membrane antigen
sporadic S-100
epithelial cells stain positive for keratin

especially EMA

Answer 18

synovial sarcoma

Question 19

over expression of CSF1 gene

Answer 19

pigmented vilonodular synovitis

recurrent atraumatic hemarthrosis is hallmark of this

Question 20

t(11;22)

Answer 20

Ewing sarcoma

Question 21

CD99 (in 95%)
MIC2
vimentin
PAS positive (intracellular glycogen)

Answer 21

Ewing sarcoma

Question 22

most common location for tumoral calcinosis ?

Answer 22

hip trochanteric bursa

Question 23

12;22

Answer 23

Clear cell sarcoma

Question 24

9;22

Answer 24

ES myxoid chondrosarcoma

Question 25

X;17

Answer 25

Alveolar soft part sarcoma

Question 26

17;22

Answer 26

Dermatofibrosarcoma protuberans

Question 27

actin(SMA)

Answer 27

Leiomyosarcoma

Question 28

Epithelial membrane antigen (EMA)

Answer 28

synovial sarcoma, epithelioid sarcoma

Question 29

Keratin

Answer 29

Carcinomas

Synovial sarcoma

Question 30

Desmin, myogenin

Answer 30

Rhabdo

Question 31

S100

Answer 31

MPNST

Question 32

Vimentin

Answer 32

Sarcoma

Question 33

CD99

Answer 33

Ewing

Question 34

T(16;17)

Answer 34

Aneurysmal bone cyst

Question 35

USP6 upregulation

Answer 35

ABC