Boards Drugs

Question 1

MOA Warfarin

Answer 1

inhibits the carboxylation step in the synthesis of vitamin k dependent clotting factors II, VII, IX and X

Reversal of anticoag med is vit K and/or FFP

Question 2

Reversal of heparin

Answer 2

pratomine sulfate

Question 3

MOA TXA

Answer 3

amino acid (lysine) analog that prevents degradation of clot by preventing formation of plasmin from plasminogen

Question 4

Botulism MOA

Answer 4

blocks presynaptic release of acetylcholine

Question 5

Baclofen

Answer 5

Gamma aminobutryic acid (GABA) agonist

effects more centrally. Occurs primarily at spinal cord level to inhibit the transmission of both monosynaptic and polysynaptic reflexes.

Question 6

Lidocaine

Answer 6

blocks voltage gated sodium channels

Question 7

MOA Abatacept

Answer 7

MHC receptor antagonist

Question 8

Adalimumab

Answer 8

TNF a

Question 9

Infliximab

Answer 9

TNF a

Question 10

Inhibition of which enzyme results in the pharmacologic antipyretic effect of acetaminophen?

Answer 10

IL1-beta

Question 11

MOA penicillins

Answer 11

inteferes with bacterial cell wall synthesis disrupts the synthesis of the peptidoglycan layer of bacterial cell walls

Question 12

MOA cephalosporins

Answer 12

disrupts the synthesis of the peptidoglycan layer of bacterial cell walls

Does so through competitive inhibition on PCB

Question 13

MOA Fluoroquinolones

Answer 13

blocks DNA replication via inhibition of DNA gyrase

Question 14

MOA aminoglycosides

Answer 14

-cidal

binding to the 30s ribosome subunit, leading to the misreading of mRNA – results in the synthesis of abnormal peptides that accumulate intracellularly and eventually lead to cell death

gentamycin

Question 15

Vancomycin

Answer 15

-cidal

inhibitor of cell wall synthesis

Inhibits cell wall synthesis by binding to the D-Ala-D-Ala terminal of the growing peptide chain during cell wall synthesis, resulting in inhibition of the transpeptidase, which prevents further elongation and cross-linking of the peptidoglycan matrix

Question 16

MOA Rifampin

Answer 16

inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase

Question 17

MOA linezolid

Answer 17

binds to the 23S portion of the 50S subunit and acts by preventing the formation of the initiation complex between the the 30S and 50S subunits of the ribosome

Question 18

Anti 50s ribosome abx

Answer 18

Macrolides 
Chloramphenicol
Lincosamide 
Linezolid 
Stretogramins

Question 19

MOA acetominophen

Answer 19

inhibits prostaglandin E2 production through its effect on interleukin-1 beta.

Question 20

MOA pregabalin and gabapentin

Answer 20

reduce hyper-excitability of voltage dependent Ca2+ channels in activated neurons.

gabapentin: binds presynaptic calcium channels to inhibit release of neurotransmitters