Oncology

Question 1

Tumor marker: CA 125

Answer 1

epithelial ovarian cancer (can be elevated in endometriosis, uterine myomas, salpingitis, PID)

Question 2

Tumor marker: hCG

Answer 2

embryonal cell carcinomas
ovarian choriocarcinomas
seminoma
mixed germ cell
some dysgerminomas

Question 3

Tumor marker: AFP

Answer 3

Yolk sac tumors
embryonal cell carcinomas
mixed germ cell
some immature teratomas

Question 4

Tumor marker: LDH

Answer 4

Dysgerminoma

Question 5

Tumor maker: Inhibin

Answer 5

epithelial stroma tumors: mucinous and endometrioid carcinoma
sex cord stromal tumors: granulosa cell tumor and sertoli leydig cell tumor

Question 6

what is the most common genetic alteration in pancreatic cancer?

Answer 6

k-ras (80-100% of panc ca), oncogene

Question 7

genetic mutation: DPC4

Answer 7

pancreatic cancer (50% of panc ca) (tumor suppressor genes)

Question 8

MOA imatinib and what is it used for?

Answer 8

tyrosine kinase inhibitor used in GISTS: NAC = mets or unresectable, adjuvant = high risk features

Question 9

what is seen on endoscopic US for GIST?

Answer 9

hypoechoic solid tumor continuous with muscularis mucosa, round submucosal lesion in stomach

Question 10

which cancer is the most sensitive to radiation therapy?

Answer 10

seminoma

Question 11

colon cancer RARELY mets to bone- what is mechanism when it does?

Answer 11

isolated mets to sacrum or vertebral bodies when tumor emboli travel though Batson plexus (portal-vertebral venous communications)

Question 12

Name cancer assoc: HTLV type 1

Answer 12

adult t cell leukemia

Question 13

Name cancer assoc: EBV

Answer 13

Burkitt lymphoma, B cell lymphoma, nasophayngeal cancer

Question 14

Name cancer assoc: hep B

Answer 14

HCC

Question 15

Name cancer assoc: hep c

Answer 15

HCC

Question 16

Name cancer assoc: h pylori

Answer 16

MALT: mucosa assoc lymphoid tissue lymphoma

Question 17

treatment of MALT lymphoma?

Answer 17

Stage 1 and 2: triple/quadruple therapy for h pylori

High grade, Stag III or IV: CHOP +/- radiation

Question 18

Name cancer assoc: vinyl chloride

Answer 18

hepatic angiosarcoma

Question 19

Name the chemotherapy agent: hemorrhagic cystitis

Answer 19

cyclophosphamide

Question 20

Name the chemotherapy agent: cardiomyopathy

Answer 20

doxorubicin/daunorubicin

Question 21

Name the chemotherapy agent: neurotoxicity

Answer 21

vincristine

Question 22

Name the chemotherapy agent: pulmonary fibrosis

Answer 22

bleomycin

Question 23

Name cancer assoc: HPV

Answer 23

anal cancer and cervical

Question 24

Name cancer assoc: HHV-8

Answer 24

kaposi’s sarcoma

Question 25

management of malignant fibrous histiocytoma of bone?

Answer 25

NAC + wide margin excision (urgent resection if high risk for pathologic fx)

Question 26

most common cancer to metastasize to small bowel?

Answer 26

melanoma