oncology Flashcards
1
Q
where are bone mets typically due to?
A
breast bronchus thyroid kidney prostate
2
Q
what is are 2 major risks of tamoxifen?
A
endometrial cancer - as stimulates endometrium (as well as bones)
thromboembolic events - aromatase inhibitors being used more instead in postmenopausal women
3
Q
tamoxifen - 2 SEs
A
hot flushes
vaginal dryness
4
Q
explain oestrogen synthesis
A
premenopausal - 95% of oestrogens produced by ovary
postmenopausal - produced in peripheral tissues (fat, skin, breast) by conversion of androstenedione from the adrenal, which involves the enzyme aromatase
5
Q
what do aromatase inhibitors do in BC treatment?
A
reduce oestrogen levels in postmenopausal women
6
Q
one risk of aromatase inhibitors
A
osteoporosis
