Oncology

Question 1

Which 3 factors can help diagnose tumour lysis syndrome?

Answer 1

you require either increased serum creatinine, a cardiac arrhythmia or a seizure to have occurred

Question 2

How do you diagnose tumour lysis syndrome?

Answer 2

you require both a positive laboratory TLS and positive clinical TLS

Question 3

What factors are required for a positive laboratory tumour lysis syndrome?

Answer 3

Positive laboratory TLS requires 2 or more of the below within 7 days of chemotherapy or 3 days before:
uric acid > 475umol/l or 25% increase
potassium > 6 mmol/l or 25% increase
phosphate > 1.125mmol/l or 25% increase
calcium < 1.75mmol/l or 25% decrease

Question 4

What factors are required for a positive clincial tumour lysis syndrome?

Answer 4

Positive clinical TLS requires any one of:
increased serum creatinine (1.5 times upper limit of normal)
cardiac arrhythmia or sudden death
seizure