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ALS > Oncology > Flashcards

Oncology Flashcards

1
Q

What are the RF for melanoma?

A

> 10 dysplastic naevi, >100 common aquired naevi, fair skin, red hair and high intermittent sun exposure e.g. blistering skin burns

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2
Q

What are the RF for melanoma?

A

> 10 dysplastic naevi, >100 common aquired naevi, fair skin, red hair and high intermittent sun exposure e.g. blistering skin burns

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3
Q

Epi of melanoma? Age, country?

A

mean age 45-55 y
1ST = NZ
2ND = Australia

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4
Q

Prevention and screening?

A

Non invasive skin examinations.

Goal of screening is to identify lesions before the vertical phase

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5
Q

ABCDE of melanoma?

A 
A= assym
B= borders
C= colour
D= diameter > 6 mm change
E = Enlargement or evolution
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6
Q

What are the poor prognostic findings?

A

Ulceration
Bleeding
Elevated LDH

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7
Q

What are the subtypes of melanoma?

A 
Superficial spreading (60-70%)
Nodular melanoma (15-30%)
Lentigo maligna melanoma (5%)
Acral lentiginous melanoma
Desmoplastic
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8
Q

which stain is used to Dx melanoma on immunohistochemistry?

A

S100. stains melanin A.

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9
Q

What is the AJCC staging for melanoma?

A 
1A = Tumour  4mm with ulceration
2C= Tumour > 4 mm with ulceration
3A= Tumour of any thickness without ulceration with 1 positive lymph node
3B = Tumour of any thickness w/o ulceration and 2-3 lymph nodes
3C = Tumour of any thickness with in-transit mets/satellite w/o lymph nodes or >= 4 lymph nodes or any primary lesion that is ulcerated
IVA = Subcutaneous or nodal mets and normal LDH
IVB = Lung mets and normal LDH
IVC = other sites of metastatic disease or elevated LDH
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10
Q

What are the 3 prognostic factors for stage III melanoma?

A
  1. Number of metastatic nodes
  2. micormets vs macromets
  3. Primary melanoma ulceration
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11
Q

what are the common site of mets for melanoma?

Uncommon sites?

A

Skin, Brain, lung, liver, bone

Small bowel, kidney, spleen , heart

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12
Q

what is the only curative option?

A

surgical resection of mets i.e. metastectomy

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13
Q

When is stereotactic radiosurgery recommended for brain mets?

A
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14
Q

which chemotherapy agents are used in melanoma Tx?

A

DTIC, platinum agents, nitrosoureas and microtubular toxins.

No agent alone or in combination have shown response rates > 25% and responses are of short duration

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15
Q

Epi of melanoma? Age, country?

A

mean age 45-55 y
1ST = NZ
2ND = Australia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Prevention and screening?

A

Non invasive skin examinations.

Goal of screening is to identify lesions before the vertical phase

17
Q

ABCDE of melanoma?

A 
A= assym
B= borders
C= colour
D= diameter > 6 mm change
E = Enlargement or evolution
18
Q

What are the poor prognostic findings?

A

Ulceration
Bleeding
Elevated LDH

19
Q

What are the subtypes of melanoma?

A 
Superficial spreading (60-70%)
Nodular melanoma (15-30%)
Lentigo maligna melanoma (5%)
Acral lentiginous melanoma
Desmoplastic
20
Q

which stain is used to Dx melanoma on immunohistochemistry?

A

S100. stains melanin A.

21
Q

What is the AJCC staging for melanoma?

A 
1A = Tumour  4mm with ulceration
2C= Tumour > 4 mm with ulceration
3A= Tumour of any thickness without ulceration with 1 positive lymph node
3B = Tumour of any thickness w/o ulceration and 2-3 lymph nodes
3C = Tumour of any thickness with in-transit mets/satellite w/o lymph nodes or >= 4 lymph nodes or any primary lesion that is ulcerated
IVA = Subcutaneous or nodal mets and normal LDH
IVB = Lung mets and normal LDH
IVC = other sites of metastatic disease or elevated LDH
22
Q

What are the 3 prognostic factors for stage III melanoma?

A
  1. Number of metastatic nodes
  2. micormets vs macromets
  3. Primary melanoma ulceration
23
Q

what are the common site of mets for melanoma?

Uncommon sites?

A

Skin, Brain, lung, liver, bone

Small bowel, kidney, spleen , heart

24
Q

what is the only curative option?

A

surgical resection of mets i.e. metastectomy

25
Q

When is stereotactic radiosurgery recommended for brain mets?

A
26
Q

which chemotherapy agents are used in melanoma Tx?

A

DTIC, platinum agents, nitrosoureas and microtubular toxins.

No agent alone or in combination have shown response rates > 25% and responses are of short duration

ALS (8 decks)

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