Oncology Flashcards
What are the RF for melanoma?
> 10 dysplastic naevi, >100 common aquired naevi, fair skin, red hair and high intermittent sun exposure e.g. blistering skin burns
What are the RF for melanoma?
> 10 dysplastic naevi, >100 common aquired naevi, fair skin, red hair and high intermittent sun exposure e.g. blistering skin burns
Epi of melanoma? Age, country?
mean age 45-55 y
1ST = NZ
2ND = Australia
Prevention and screening?
Non invasive skin examinations.
Goal of screening is to identify lesions before the vertical phase
ABCDE of melanoma?
A= assym B= borders C= colour D= diameter > 6 mm change E = Enlargement or evolution
What are the poor prognostic findings?
Ulceration
Bleeding
Elevated LDH
What are the subtypes of melanoma?
Superficial spreading (60-70%) Nodular melanoma (15-30%) Lentigo maligna melanoma (5%) Acral lentiginous melanoma Desmoplastic
which stain is used to Dx melanoma on immunohistochemistry?
S100. stains melanin A.
What is the AJCC staging for melanoma?
1A = Tumour 4mm with ulceration 2C= Tumour > 4 mm with ulceration 3A= Tumour of any thickness without ulceration with 1 positive lymph node 3B = Tumour of any thickness w/o ulceration and 2-3 lymph nodes 3C = Tumour of any thickness with in-transit mets/satellite w/o lymph nodes or >= 4 lymph nodes or any primary lesion that is ulcerated IVA = Subcutaneous or nodal mets and normal LDH IVB = Lung mets and normal LDH IVC = other sites of metastatic disease or elevated LDH
What are the 3 prognostic factors for stage III melanoma?
- Number of metastatic nodes
- micormets vs macromets
- Primary melanoma ulceration
what are the common site of mets for melanoma?
Uncommon sites?
Skin, Brain, lung, liver, bone
Small bowel, kidney, spleen , heart
what is the only curative option?
surgical resection of mets i.e. metastectomy
When is stereotactic radiosurgery recommended for brain mets?
which chemotherapy agents are used in melanoma Tx?
DTIC, platinum agents, nitrosoureas and microtubular toxins.
No agent alone or in combination have shown response rates > 25% and responses are of short duration
Epi of melanoma? Age, country?
mean age 45-55 y
1ST = NZ
2ND = Australia
Prevention and screening?
Non invasive skin examinations.
Goal of screening is to identify lesions before the vertical phase
ABCDE of melanoma?
A= assym B= borders C= colour D= diameter > 6 mm change E = Enlargement or evolution
What are the poor prognostic findings?
Ulceration
Bleeding
Elevated LDH
What are the subtypes of melanoma?
Superficial spreading (60-70%) Nodular melanoma (15-30%) Lentigo maligna melanoma (5%) Acral lentiginous melanoma Desmoplastic
which stain is used to Dx melanoma on immunohistochemistry?
S100. stains melanin A.
What is the AJCC staging for melanoma?
1A = Tumour 4mm with ulceration 2C= Tumour > 4 mm with ulceration 3A= Tumour of any thickness without ulceration with 1 positive lymph node 3B = Tumour of any thickness w/o ulceration and 2-3 lymph nodes 3C = Tumour of any thickness with in-transit mets/satellite w/o lymph nodes or >= 4 lymph nodes or any primary lesion that is ulcerated IVA = Subcutaneous or nodal mets and normal LDH IVB = Lung mets and normal LDH IVC = other sites of metastatic disease or elevated LDH
What are the 3 prognostic factors for stage III melanoma?
- Number of metastatic nodes
- micormets vs macromets
- Primary melanoma ulceration
what are the common site of mets for melanoma?
Uncommon sites?
Skin, Brain, lung, liver, bone
Small bowel, kidney, spleen , heart
what is the only curative option?
surgical resection of mets i.e. metastectomy
