Oncology Flashcards by SODUSTA, Gabrielle Angelic

Q

G1 presynthetic phase

A

Etoposide

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Q

S - DNA synthesis

A

Antimetabolites

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Q

G2 Premitotic phase

A

Bleomycin

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Q

M - Mitosis

A

Antimitotic

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Q

Platinum

A

Cisplatin
Carboplatin
Oxaliplatin

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Q

WOF when taking Platinum

A

Nephrotoxic, ototoxic
WTD? Hydration

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Q

Nitrogen mustard

A

Mechlorethamine

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Q

Busulfan (WOF)

A

Pulmonary fibrosis

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Q

Cyclophosphamide (WOF)

A

Toxic metabolite: Acrolein
-hemorrhagic, steril, cystisis

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Q

WTD? (WOF) of Acrolein

A

Mercaptoethane
Sulfonate sodium
“MESNa”

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Q

Antitumor antibiotic

A

Mitomycin
Bleomycin

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Q

Antitumor antibiotic (WOF)

A

Vessicant
Pulmonary fibrosis

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Q

Anthracycline

A

Doxorubicin

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Q

Doxorubicin (MOA & WOF)

A

(-) topoisomerase II = Cardiotoxicity

WTD? Dexrazoxane

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Q

Podophyllotoxin

A

Etoposide G1

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Q

Etoposide G1 (MOA & WOF)

A

(-) topoisomerase II

Bone marrow toxicity

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Q

Camptothecin

A

Irinotecan
Topotecan

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Q

Campthothecin (MOA & WOF)

A

(-) topoisomerase I

BMT
Diarrhea

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Q

Methotrexate: MOA

A

(-) dihydrofolate reductase

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Q

Methotrexate: Uses

A

1st line DMARDs vs RA
for ectopic pregnancy

Q

Methotrexate: WOF

A

-BM Toxicity
-Hepatotoxicity

WTD? Leucovorin/Folinic acid

Q

Pemetrexed: MOA

A

(-) thymidylate synthase

Q

Pemetrexed: WOF

A

Hand and Foot syndrome

Q

A

Q

Pemetrexed: WTD for toxicity?

A

Dexamethasone

Q

Pyrimidine analogues

A

Capecitabine, Cytarabine, 5-flourouracil
= colon cancer

Q

Purie analogues

A

Mercaptopurine

Q

Taxane or Vinca Alkaloids?

Effect: Assembly

A

Taxanes

Q

Taxane or Vinca Alkaloids?

Effect: Disassembly

A

Vinca alkaloids

Q

Taxane or Vinca Alkaloids?

Tavus brevifolia

A

Taxanes

Q

Taxane or Vinca Alkaloids?

Catharantus roseus “Periwinkle”

A

Vinca alkaloids

Q

Taxane or Vinca Alkaloids?

Paclitaxel
Docetaxel

A

Taxane

Q

Taxane or Vinca Alkaloids?

Vincristine and Vinblastine

A

Vinca alkaloids

Q

Taxanes WOF

A

Allergy

Q

Vincristine WOF

A

Neurotoxic

Q

Vinblastine WOF

A

Bone marrow toxicity

Q

Interleukine-2 is used for

A

Renal cell cancer

Q

Examples of Cytokine & Cytokine modifiers

A

Thalidomide (more toxic) & Lenalidomide
vs. multiple myeloma

Q

Monoclonal AB or Tyrosine kinase inhibitor

-mab

A

Monoclonal AB

Q

Monoclonal AB or Tyrosine kinase inhibitor

with extracellular target

A

Monoclonal AB

Q

Monoclonal AB or Tyrosine kinase inhibitor

AntiCD20 = drug

A

Monoclonal AB
Rituximab

Q

Monoclonal AB or Tyrosine kinase inhibitor

anti EGFR = drug

A

Monoclonal AB
Trastuzumab

Q

Monoclonal AB or Tyrosine kinase inhibitor

anti-VEGF drug

A

Monoclonal AB
Bevacizumab

Q

Monoclonal AB or Tyrosine kinase inhibitor

-inib

A

Tyrosine kinase inhibitor

Q

Monoclonal AB or Tyrosine kinase inhibitor

with intracellular target

A

Tyrosine kinase inhibitor

Q

Monoclonal AB or Tyrosine kinase inhibitor

vs. c-KIT (+) tumors

A

Tyrosine kinase inhibitor
Imatinib

Q

Monoclonal AB or Tyrosine kinase inhibitor

vs. lung cancer

A

Tyrosine kinase inhibitor
Eriotinib

Q

A