Oncology Flashcards
Treatment stage 1-2 cervical cancer with hysterectomy and pelvic node dissection
Treatment of stage 3 cervical cancer with concurrent radiation therapy and cisplatin based chemotherapy
Bowel inflammation marker
Fecal calprotectin and fecal lactoferrin
Ipilimumab and nivolumab can cause immunotherapy induced colitis
Treatment of immunotherapy induced colitis by glucocroticoid like methylprednisolone for moderate to severe diarrhea
With mild diarrhea, can use oral budesonide
If not respond to glucocorticoid, can use tnf alpha like infliximab
Ibrutinib is a first line treatment of CLL but i can cause p jirovecii pneumonia
Nonseminomatous germ cell tumors will have elevated afp
Programmed death receptor 1 PDL1 inhibitor can use to treat mismatch repair deficient colon cancer, not in proficient colon cancer
Advanced ovarian cancer and BRCA1 mutation can receive maintenance therapy with a poly APD ribose polymerase inhibitor
Fluoxetine paroxetine and bupropion are strong cyp2d6 and may interact with tamoxifen
Sertraline escitalopram venlafaxine are safe with tamoxifen
Giving radiation therapy before surgery increase the risk of poor wound healing and other complication
Rasburicase is contrandicated in g6pd deficiency
Acetazolamide and bicarb should not be used in tumor lysis syndrome because i can cause urine alkalization and cause hyperphosphatemia and calcium phosphate crystal
Prophylactic cranial irradiation can be used in small cell lung cancer
Antibiotic treating h pylori just works in gastric MALT lymphoma
Teriparatide is contraindicated for patient with a history of irradiation due to concerns of osteosarcoma in the treatment field
Treat emesis due to chemo by ondansetron aprepitant dexamethasone and olanzapine
Treat hypercalcemia due to malignancy by iv fluid and calcitonin
Biohosphonates is contraindicated in kidney failure buy denosumab can be used
Treat non small cell lung cancer with an ALK translocation with alectinib
Smudge cells in CLL
Positive with cd5 cd19 and cd20
With low risk cervical cancer, treat with radical trachelectomy or cervical conization
Braf mutation is important in melanoma
Treat with tyrosine kinase inhibitor
Egfr mutation is in non small cell lung cancer, treat with anti egfr tyrosine kinase inhibitors
Pt with new diagnosis of colon cancer require evaluation of mismatch repair protein expression status
All metastatic colorectal cancer require tumor genotyping for KRAS, BRAF, NRAS mutation
If tumor do not have these mutation, it will respond to cetuximab and panitumumab
Non small cell lung cancer need test for egfr mutation and translocation of ALK and ROS1
If egfr positive treat with erlotinib or osimetinib
If positive for alk or ros1 translocation treat with alectinib
Exemestane, an aromatase inhibitor do not cause vte
HPV associated with largely cystic mass squamous cell carcinoma
Her2 positive is a risk factor for local recurrence and need radiation therapy
If braf non mutated melanoma, can treat by ipilimumab, an anti CTLA 4 antibody and nivolumab or pembrolizumab, an anti PD1 antibody
Tamoxifen work both pre and post menopause
Aromatase inhibitor not effective in pre menopause, just work on post menopause
