Oncology Flashcards
Doxorubicin side effects
Dilated cardiomyopathy
Osteomyelitis x-ray
periosteal reaction
Osteosarcoma x-ray
Sunburst
metaphysis or growth plate
Ewing sarcoma
onion skinning
Mottled
diaphysis and axial
Langerhans cell histiocytosis
1-Rash
2-neutropneia
3-Skull abnormalities
4-DI (polyuria and polydipsia)
Neuroblastoma
Opsoclonus-myoclonus
Dx: urine VMA/HVA
or MIBG scintigraphy
12-year-old female, with fatigue, diffuse lymphadenopathy, HSM, supraclavicular lymph node, normal Hb and WBC, and low normal platelets 150s. Viral studies (EBV) normal. What is the NEXT best step?
CXR
WAGR
Wilams Tumor
Aniridia
GU abnormalities
retreated mentally
5yo with LCH s/p chemotherapy with vinblastine and prednisone 1 year prior, currently in remission. Presenting with polyuria and polydipsia. What is the cause?
Central diabetes insipidus
Kid with Burkitt’s and TLS. Urine pH 7.0. What’s next.
Rasburicase
Features of Tumor lysis syndrome
Remember cells are bursting
1-high K
2-high phosphate
3-low ca
4-high ca in the urine
5-high LDH
Tumor lysis management
Allopurinol: decreases production of urate
Rasbirucase: binds urate to excrete it
A child with ALL finished chemo 1 month ago and is exposed to Varicella. How do you treat?
VZIG
Examples of live vaccine
MMR, varicella, rotavirus
Nasal flu
BCG, Zoster
Chemotherapy that causes low sodium and vomiting
Cyclophosphamide