Oncology

Question 1

Wilm’s Tumor/Nephroblastoma

Answer 1

Commonly presents as asymptomatic mass with mean age of dx of 3.5. Abdo pain (40%), hematuria (20%), hypertension, hemihypertrophy and aniridia.
Metastasize by blood/lymph: bone, lung, brain, liver.
Good prognosis, 80-90% survival with chemo, radiation and surgery.
Aniridia and wilm’s are both associated with Chromosome 11.

Question 2

Acute splenic sequestration

bite cells and Heinz bodies. big sequestration of cells into the spleen causing hypovolemia and circulatory collapse.

Answer 2

bite cells and Heinz bodies. big sequestration of cells into the spleen causing hypovolemia and circulatory collapse.

Question 3

Beckwidth Wiedeman Syndrome

Answer 3

Overgrowth disorder. Macrosomia, visceromegaly, macroglossia, hyperinsulinemic hypoglycemia, midline defects. Ear tags/pits. Associated with wilm’s Tumor.

Question 4

WAGR Syndrome

Answer 4

Wilm’s Tumor, Aniridia, GU abnormalities, mental retardation.

Question 5

Fever, abdominal mass, bone pain, limp, irritability and diarrhea….

Answer 5

neuroblastoma probably.

Question 6

Prognostic factors for ALL

Answer 6

Bad: thymic variants mostly - age 10, CNS leukemia, platelets <100 000, mediastinal mass.

Question 7

Acute splenic sequestration

Answer 7

bite cells and Heinz bodies. big sequestration of cells into the spleen causing hypovolemia and circulatory collapse.

Question 7

Drugs causing mucositis

Answer 7

Methotrexate usually. Also doxorubicin.