Oncology

Question 1

BRCA2 mutation - association with what cancers? What chromosome?

Answer 1

Chromosome 13
Breast
Ovarian
Prostate

Question 2

BRCA1 mutation - association with what cancers? What chromosome?

Answer 2

Chromosome 17
Ovarian
Young onset Colorectal

Question 3

Lynnch syndrome

Answer 3

Patients identified using the Amsterdam criteria.
At risk of early onset colonic and endometrial ca
Autosomal DOMINANT

Question 4

Gardners syndrome

Answer 4

Autosomal DOMINANT
Familial colorectal polyposis
Desmoid tumours
Mutation on APC gene (Ch5)
A variant of FAP

Question 5

Li-Fraumeni Syndrome

Answer 5

Autosomal DOMINANT
Germline mutations to p53 tumour suppressor gene
Sarcomas and Leukaemia

Question 6

Adverse effect of cyclophosphamide

Answer 6

Haemorrhagic cystitis
Myelosuppression
TCC

Question 7

Adverse effect of Bleomycin

Answer 7

Lung fibrosis

Question 8

Adverse effect of doxorubicin

Answer 8

cardiomyopathy

Question 9

Adverse effect of methotrexate

Answer 9

Myelosuppression
Liver fibrosis
Lung fibrosis
Mucositis

Question 10

Adverse effect of Flurouracil

Answer 10

Myelosuppression
Mucositis
Dermatitis

Question 11

Adverse effect of 6-mercaptopurine

Answer 11

Myelosuppression

Question 12

Adverse effect of cytarabine

Answer 12

Myelosuppression
Ataxia

Question 13

Adverse effect of docetaxel

Answer 13

Neutropenia

Question 14

Adverse effect of cisplatin

Answer 14

Ototoxicity
Peripheral neuropathy
Hypomagnesaemia

Question 15

Tumour markers

Answer 15

CA 125 Ovarian cancer
CA 19-9 Pancreatic cancer
CA 15-3 Breast cancer
PSA Prostatic carcinoma
AFP Hepatocellular carcinoma, teratoma
CEA Colorectal cancer
S-100 Melanoma, schwannomas
Bombesin Small cell lung carcinoma, gastric cancer, neuroblastoma

Calcitonin Medullary thyroid cancer