Metabolic medicine Flashcards
Vitamin A
- Name
- Deficiency causes
Retinoid
Nightblindness (NYCTALOPIA)
Vitamin B1
- Name
- Deficiency causes
Thiamine
Beri-Beri - Wet vs Dry
- Wernicke-Korsakoff syndrome
- Polyneuropathy
- Heart failure
Vitamin B3
- Name
- Deficiency causes
Niacin
Causes Pellagra
- Dermatitis
- Diarrhoea
- Dementia
Vitamin B6
Pyridoxine
- Anaemia, seizures, irritability
Vitamin B7
Biotin
Dermatitis, Seborrhoea
Vitamin B9
Folic acid
- Megaloblastic anaemia, neural tube defects during pregnancy
Vitamin B12
Cyanocobalamin
- Megaloblastic anaemia, peripheral neuropathy
Vitamin C
Ascorbic acid
- Scurvy (gingivitis, bleeding)
Vitamin D
Colecalciferol
- Rickets, Osteomalacia
Vitamin E
Tocopherol
- Haemolytic anaemia in newborns
- Ataxia
- Peripheral neuropathy
Vitamin K
Naphthoquinone
- Bleeding
Statin choice - primary vs secondary prevention
NICE 2014:
Primary=Q-Risk>10%=Atorvastatin 20mg
Secondary=IHD/CVD/PVD=Atorvastatin 80mg
Factors which may underestimate QRISK score…
HIV treatment,
mental health problems,
steroids,
immunosuppressants,
autoimmune disorders
consider the possibility of familial hypercholesterolaemia when…
Total cholesterol >7.5
and/or
FHx of CVD event <60y/o
Follow-up of people started on statins
NICE recommend we follow-up patients at 3 months
- repeat a full lipid profile
- if the non-HDL cholesterol has not fallen by at least 40% concordance and lifestyle changes should be discussed with the patient
- NICE recommend we consider increasing the dose of atorvastatin up to 80mg
