Oncology Flashcards
Smooth muscle actin (SMa)
smooth muscle –> leiomyosarcoma
Desmin
skeletal muscle –> rhabdomyosarcoma
S-100
neural –> schwannoma, MPNST
CD34/CD31
endothelial cell –> hemangioma, angiosarcoma
beta catenin
membrane marker/WNT pathway –> fibromatosis
CD99
Ewing’s
IN1 (integrase interactor 1)
epithelioid sarcoma
Keratin
epithelioid sarcoma, synovial sarcoma, carcinoma
EMA (epithelial membrane antigen)
epithelioid sarcomas, synovial sarcomas
Myod1/Myogenin (Myf-4)
skeletal muscle –> rhabdomyosarcoma
vimentin
soft tissue sarcoma
Ewing’s chromosomal abnormality and gene
t(11;22)
EWS-FLI1
Myxoid liposarcoma chromosomal abnormality and gene
t(12;16)
TLS-CHOP
Alveolar rhabdomyosarcoma chromosomal abnormality and gene
t(2;13)
PAX3-FKHR
Clear cell sarcoma chromosomal abnormality and gene
t(12;22)
EWS-ATF1
Synovial Sarcoma chromosomal abnormality and gene
t(X;18)
SSX1-SYT
Myxoid chondrosarcoma chromosomal abnormality and gene
t(9;22)
EWS-CHN
Fibrosarcoma histology
herringbone pattern
Malignant peripheral nerve sheath tumor gene and histology
gene: NF1
histology: spindle cells in a whirling pattern, S100 positive
Angiosarcoma histology
- epithelioid nests
- spindle cells
- rudiementary vascular channels (how to differentiate from other sarcomas)
- CD 34
Loss of IN1
epithelioid sarcoma
Epithelioid sarcoma histology
nodular growth pattern, mixed polygonal cells with eosinophilic cytoplasm mixed with spindle and epithelioid cells
Fibromatosis on MRI
dark on T1 and T2
Pathology of extra abdominal desmoid
spindle cells in a collagenous stroma
invades muscle
IHC beta catenin
estrogen receptor
Schwannoma/Neurilemmoma histology
nuclear palisading with verocay bodies (Antoni A) and loose haphazard collagen matrix (Antoni B)
Periosteal osteosarcoma histology
chondroblastic components with malignant bone formation
Treatment of periosteal osteosarcoma
same as conventional (chemo and surgery)
Histology of telangiectatic OSA
- malignant osteoid
- vascular lakes and channels
- giant cells
Histology of NOF
spindle shaped fibroblasts, whorled pattern, giant cells, hemosiderin
Lymphoma differentiators from other blue cell tumors
CD45+
LCA (leukocyte common antigen)
Ewings differentiators from other blue cell tumors
vimentin positive
keratin positive
CD99 positive
Rhabdomyosarcoma differentiators from other blue cell tumors
Desmin positive
Neuroblastoma differentiators from other blue cell tumors
NSE (neuron specific endolase)
NB 84
Myeloma differentiators from other blue cell tumors
CD56+
CD20+
Skeletal metastases most commonly occur in…
the spine due to batson’s plexus.
The most common location for localized PVNS is…
anterior knee.
