Oncology 1

Question 1

Dosing Consideration for Select Highly Toxic Drugs

Answer 1

Bleomycin - lifetime cumulative dose 400 units = pulmonary toxicity
Doxorubicin - lifetime cumulative dose 450-550 mg = cardiotoxicity
Cisplatin - dose per cycle not to exceed 100 mg = nephrotoxicity
Vincristine - single dose “capped” at 2 mg = neuropathy

Question 2

Dexrazoxane

Answer 2

Zinecard - prophylaxis to prevent cardiomyopathy

Totect - treatment for extravasation

Question 3

Filgrastim

Answer 3

Neuopogen

Question 4

Pegfilgrastim

Answer 4

Neulasta

Question 5

Epoetin alfa

Answer 5

Epogen, Procrit

Question 6

Darbepoetin alfa

Answer 6

Aranesp

Question 7

Aprepitant

Answer 7

Emend - capsule, suspension, injection

Question 8

Fosaprepitant

Answer 8

Emend - Injection

Question 9

Ondansetron

Answer 9

Zofran, Zuplenz film

Question 10

Granisetron

Answer 10

Sancuso

Question 11

Palonosetron

Answer 11

Aloxi

Question 12

Dexamethasone

Answer 12

Decadron

Question 13

Prochlorperazine

Answer 13

Compazine

Question 14

Promethazine

Answer 14

Phenergan - do not use in children < 2 years; do not give via intra-arterial or SC administration; IV route can cause serious tissue injury if extravasation occurs

Question 15

Metochlopramide

Answer 15

Reglan - tardive dyskinesia that can be irreversible

Question 16

Olanzapine

Answer 16

Zyprexa

Question 17

Dronabinol

Answer 17

Marinol
Capsules: C-III
Solution: C-II
Refrigerate

Question 18

Nabilone

Answer 18

Cesamet

C-II

Question 19

Lorazepam

Answer 19

Ativan

C-IV

Question 20

Myelosuppression

Answer 20

Almost all classic chemotherapy drugs, except:

Asparaginase, bleomycin, vincristine

Question 21

Nausea and vomiting

Answer 21

Cisplatin, cyclophosphamide, ifosfamide

Question 22

Mucositis

Answer 22

Fluorouracil and methotrexate

Question 23

Diarrhea

Answer 23

Irinotecan, capecitabine, fluorouracil and methotrexate

Question 24

Constipation

Answer 24

Vincristine

Question 25

Xerostomia

Answer 25

Caused by radiation therapy to the head or neck regions

Question 26

Cardiotoxicity

Answer 26

Cardiomyopathy: anthracyclines

QT prolongation: arsenic trioxide, many TKIs

Question 27

Pulmonary Toxicity

Answer 27

Pulmonary fibrosis: bleomycin, busulfan, carmustine, lomustine
Pneumonitis: immune therapy MAbs

Question 28

Hepatotoxicity

Answer 28

Antiandrogens (bicalutamide, flutamide, nilutamide)

Question 29

Nephrotoxicity

Answer 29

Cisplatin, methotrexate

Question 30

Hemorrhagic cystitis

Answer 30

Ifosfamide (all doses), cyclophosphamide (higher doses)

Question 31

Neuropathy

Answer 31

Vinca alkaloids, platinum, taxanes

Question 32

Thromboembolic risk

Answer 32

Aromatase inhibitors (anastrozole, letrozole) SERMs (tamoxifen, raloxifene)