Oncogenes and Tumors Flashcards
1
Q
What are oncogenes
A
genes that promote autonomous cell growth
2
Q
proto-oncogenes
A
normal cellular counterpart
3
Q
proto-oncogene and mutation yield
A
oncogene
4
Q
oncoprotein
A
product of oncogene
5
Q
Gain of function means
A
aberrant expression or inappropriate production of structurally normal protein
6
Q
translocation genes
A
dysregulation of gene expresssion
7
Q
Translocation genes that dysregulate gene expression
A
C-MYC (burkitt lymphoma) BCL2 (follicular lymphoma)
8
Q
Translocations causing structural alteration gene
A
BCR/ABL chromic myeloid leukemia
9
Q
Example of a deletion gene
A
RB (retinoblastoma)
10
Q
Gene amplification gene ex
A
N-MYC neuroblastoma and HER-2 (breast cancer)
