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MOD 2 > Oncogenes > Flashcards

Oncogenes Flashcards

1
Q

ERBB1 (EGFR)

oncogene

A

mutation -> Adenocarcinoma of Lung.

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2
Q

ERBB2 (HER2)

oncogene

A

amplification -> Breast carcinoma

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3
Q

PDGF (oncogene)

A

overexpression or translocation -> glioma/leukemia

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4
Q

ALK (RTK)

oncogene

A

point mutation -> neuroblastoma.

translocation -> adenocarcinoma of lung, lymphoma.

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5
Q

RAS (oncogene)

A

point mutation -> (90% of) Pancreatic adenocarcinoma and Cholangiocarcinoma.

Cytoplasmic kinases

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6
Q

BRAF (oncogene)

A

Hairy Cell Leukemia

Melanoma

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7
Q

MYC (oncogene)

A

translocation (8;14) -> Burkitt Lymphoma

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8
Q

NMYC (oncogene)

A

amplification -> Neuroblastoma

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9
Q

BCR-ABL (oncogene)

A

Translocation (9;22) -> Chronic Myelogenous Leukemia.

Increased Intercellular tyrosine kinase activity.

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10
Q

TP53 (tumor suppressors)

A

most frequently mutated gene in cancer.

Li-Fraumeni Syndrome (SBLA- sarcoma, breast, leukemia, adrenal)

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11
Q

APC (tumor suppressors)

A

Blocks B-catenin growth signals to GI epithelium via WNT signaling pathway.

Familial Adenomatous Polyposis (FAP)

Carcinoma of colon, stomach, pancreas. Melanoma.

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12
Q

NF1 (tumor suppressors)

A

Neurofibromatosis I: benign neurofibromas and gliomas.

neuroblastoma and juvenile myeloid leukemia

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13
Q

NF2 (tumor suppressors)

A

acoustic schwannoma.

meningioma

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14
Q

RB (tumor suppressors)

A

Retinoblastoma - del(13q14)

osteosarcoma

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15
Q

VHL (tumor suppressors)

A

Von Hippel Lindau syndrome - del(3p)

Renal cell carcinoma and Pheochromocytoma

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16
Q

CDH1 (E-cadherin) (tumor suppressors)

A

Familial gastric carcinoma

Disruption allows metastasis in sporadic cancers

17
Q

WT1 (tumor suppressors)

A

Wilms Tumor

18
Q

CDKN2A (tumor suppressors) and p16/INK4a

A

familial melanoma

19
Q

PTEN (tumor suppressors)

A

Cowden Syndrome: frequent benign tumors

20
Q

PTCH1 (tumor suppressors)

A

Gorlin syndrome - Basal cell carcinoma and medulloblastoma

Related to SHH

21
Q

MSH (tumor suppressors)

A

endometrial and colon carcinoma

Only AR tumor suppressor mutation

22
Q

BCL2

A

Anti apoptosis

Follicular lymphoma t(14;18)

23
Q

TGF-B

A

Inhibits cell proliferation.

Carcinomas

MOD 2 (3 decks)

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