Oncogenes

Question 1

BCR-ABL gene product

Answer 1

tyrosine kinase

Question 2

BCR-ABL assd tumor

Answer 2

CML, ALL

Question 3

BCL-2 gene product

Answer 3

antiapoptotic molecule (inhibits apoptosis)

Question 4

BCL-2 assd tumor

Answer 4

follicular and undifferentiated lymphomas

Question 5

BRAF gene product

Answer 5

serine/threonine kinase

Question 6

BRAF assd tumor

Answer 6

melanoma, non-Hodgkin lymphoma

Question 7

ckit gene product

Answer 7

cytokine receptor

Question 8

c-kit assd tumor

Answer 8

gastrointestinal stromal tumor (GIST)

Question 9

c-myc assd tumor

Answer 9

Burkitt lymphoma

Question 10

c-myc gene product

Answer 10

transcription factor

Question 11

HER2/neu (c-erbB2) assd tumor

Answer 11

breast, ovarian, and gastric carcinomas

Question 12

HER2/neu (c-erbB2) assd gene product

Answer 12

tyrosine kinase

Question 13

L-myc assd tumor

Answer 13

Lung Tumor

Question 14

L-myc gene product

Answer 14

transcription factor

Question 15

N-myc associated tumor

Answer 15

Neuroblastoma

Question 16

N-myc gene product

Answer 16

transcription factor

Question 17

RAS gene product

Answer 17

GTPase

Question 18

RAS associated tumor

Answer 18

colon cancer, lung cancer, pancreatic cancer

Question 19

RET gene product

Answer 19

tyrosine kinase

Question 20

RET associated tumor

Answer 20

MEN 2A and 2B, medullary thyroid cancer