Oncogenes

Question 1

PDGF B chain (Mode of action)

Answer 1

overexpression (Growth factor)

Question 2

ERBB2 (Her) (Mode of action)

Answer 2

amplification

Question 3

ALK (Mode of action)

Answer 3

translocation, fusion gene formation

point mutation

Question 4

RAS (Mode of action)

Answer 4

Point mutation

Question 5

ABL (Mode of action)

Answer 5

translocation, point mutation

Question 6

MYC (Mode of action)

Answer 6

translocation

Question 7

NMYC (Mode of action)

Answer 7

amplification

Question 8

Cyclin D(Mode of action)

Answer 8

translocation, amplification

Question 9

CDK4 (Mode of action)

Answer 9

amplification or point mutation

Question 10

MYC

Answer 10

burkit lymphoma

Question 11

nmyc

Answer 11

neuroblastoma

Question 12

CDK4

Answer 12

glioblastoma, melanoma, sarcoma

Question 13

ABL

Answer 13

CML (some all)

Question 14

RAS

Answer 14

many canvers

Question 15

HER

Answer 15

breast carcinoma

Question 16

ALK

Answer 16

adenocarcinoma of the lung, certain lymphomas

neuroblastoma

Question 17

RET

Answer 17

MEN, familial medullary thyroid carcinomas

Question 18

Oncogenes - Growth factors

Answer 18

PDGF, FGF, TGF-a, HGF

Question 19

Oncogenes - Growth factor receptors

Answer 19

EGF-receptor family
PDGF receptor
receptor for KIT ligand
ALK receptor

Question 20

Oncogenes - proteins involved in signal tranduction

Answer 20

RAS
ABL
BRAF
NOTCH1
 JAK 2

Question 21

Oncogenes - nuclear regulatory proteins

Answer 21

MYC

NMYC

Question 22

Oncogenes - cell cycle regulators

Answer 22

CCND1 (cyclin D1)

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