Oncogenes Flashcards
1
Q
PDGF B chain (Mode of action)
A
overexpression (Growth factor)
2
Q
ERBB2 (Her) (Mode of action)
A
amplification
3
Q
ALK (Mode of action)
A
translocation, fusion gene formation
point mutation
4
Q
RAS (Mode of action)
A
Point mutation
5
Q
ABL (Mode of action)
A
translocation, point mutation
6
Q
MYC (Mode of action)
A
translocation
7
Q
NMYC (Mode of action)
A
amplification
8
Q
Cyclin D(Mode of action)
A
translocation, amplification
9
Q
CDK4 (Mode of action)
A
amplification or point mutation
10
Q
MYC
A
burkit lymphoma
11
Q
nmyc
A
neuroblastoma
12
Q
CDK4
A
glioblastoma, melanoma, sarcoma
13
Q
ABL
A
CML (some all)
14
Q
RAS
A
many canvers
15
Q
HER
A
breast carcinoma
