Cell Cycle components and inhibitors that are frequently mutated in Cancer

Question 1

Form a complex that phophorylates RB, allowing the cell to progress through the G1 restriction point

Answer 1

CDK4, D cyclins

Question 2

block the cell cycle by bindign to cyclin CDK complexes

Answer 2

CIP/KIP family (cell cycle inhibitors)
p21 is induced by tumor supressor p53
p27 responds to growth supressors such as TGFB

Question 3

Binds to cyclin D CDK4 and promotes the inhibitory effects of RB

Answer 3

p16/INK4a (cell cycle inhbitor)

Question 4

increases p53 levels by inhibiting MDM2 activity

Answer 4

p14/ARF (cell cycle inhibitor)

Question 5

tymor supressive pocke protein that binds E2F transcription factors in its hypophophorylated state. preventing G1/S transition also interacts with several transcritption factors that regulate differentiation

Answer 5

RB

Question 6

Tumor supressor altered in the majority of cancers; causes cell cycle arrest and apoptosis. acts mainly through p21 to cause cell cycle arrest. Causes apoptosis by inducing the transcription of proapoptotic genes such as BAX. Levels of ——are negatively regulated by MDM2 through a feedback loop. —–is required for the G1/S checkpoint and is a main component of the G2/M checkpoint.

Answer 6

P53.